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A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure.
Sonett J, Goldklang M, Sklepkiewicz P, Gerber A, Trischler J, Zelonina T, Westerterp M, Lemaître V, Okada Y, D'Armiento J. Sonett J, et al. Among authors: goldklang m. FASEB J. 2018 Jun 15;32(12):fj201701381. doi: 10.1096/fj.201701381. Online ahead of print. FASEB J. 2018. PMID: 29906247 Free PMC article.
Modulation of these pathways through manipulation of ABCA1 activity effectively blocks cigarette smoke-induced inflammation and provides a potential novel therapeutic approach for the treatment of chronic obstructive pulmonary disease.-Sonett, J., Goldklang, M., Skl …
Modulation of these pathways through manipulation of ABCA1 activity effectively blocks cigarette smoke-induced inflammation and provides a p …
Maternal smoke exposure decreases mesenchymal proliferation and modulates Rho-GTPase-dependent actin cytoskeletal signaling in fetal lungs.
Unachukwu U, Trischler J, Goldklang M, Xiao R, D'Armiento J. Unachukwu U, et al. Among authors: goldklang m. FASEB J. 2017 Jun;31(6):2340-2351. doi: 10.1096/fj.201601063R. Epub 2017 Feb 16. FASEB J. 2017. PMID: 28209772 Free PMC article.
Pregnant female C57BL/6J mice were exposed to cigarette smoke (100-150 mg/m(3)) or room air, and offspring were humanely killed on 12.5, 14.5, 16.5, and 18.5 d post coitum (dpc). ...Furthermore, genome expression studies revealed a smoke-induced up-regulation of Rho-GTPase …
Pregnant female C57BL/6J mice were exposed to cigarette smoke (100-150 mg/m(3)) or room air, and offspring were humanely killed on 12 …
Second hand smoke and COPD: lessons from animal studies.
Goldklang MP, Marks SM, D'Armiento JM. Goldklang MP, et al. Front Physiol. 2013 Feb 27;4:30. doi: 10.3389/fphys.2013.00030. eCollection 2013. Front Physiol. 2013. PMID: 23450717 Free PMC article.
Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice.
Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Cloonan SM, et al. Among authors: goldklang mp. Nat Med. 2016 Feb;22(2):163-74. doi: 10.1038/nm.4021. Epub 2016 Jan 11. Nat Med. 2016. PMID: 26752519 Free PMC article.
32 results