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ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.
Kocan M, Sarwar M, Ang SY, Xiao J, Marugan JJ, Hossain MA, Wang C, Hutchinson DS, Samuel CS, Agoulnik AI, Bathgate RAD, Summers RJ. Kocan M, et al. Among authors: ang sy. Sci Rep. 2017 Jun 7;7(1):2968. doi: 10.1038/s41598-017-02916-5. Sci Rep. 2017. PMID: 28592882 Free PMC article.
Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.
Patil NA, Hughes RA, Rosengren KJ, Kocan M, Ang SY, Tailhades J, Separovic F, Summers RJ, Grosse J, Wade JD, Bathgate RA, Hossain MA. Patil NA, et al. Among authors: ang sy. J Med Chem. 2016 Mar 10;59(5):2118-25. doi: 10.1021/acs.jmedchem.5b01786. Epub 2016 Feb 12. J Med Chem. 2016. PMID: 26824523
Structure-function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins.
Littler DR, Ang SY, Moriel DG, Kocan M, Kleifeld O, Johnson MD, Tran MT, Paton AW, Paton JC, Summers RJ, Schembri MA, Rossjohn J, Beddoe T. Littler DR, et al. Among authors: ang sy. J Biol Chem. 2017 Sep 8;292(36):15143-15158. doi: 10.1074/jbc.M117.796094. Epub 2017 Jun 29. J Biol Chem. 2017. PMID: 28663369 Free PMC article.
97 results