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GSK3732394: a Multi-specific Inhibitor of HIV Entry.
Wensel D, Sun Y, Davis J, Li Z, Zhang S, McDonagh T, Langley D, Mitchell T, Tabruyn S, Nef P, Cockett M, Krystal M. Wensel D, et al. J Virol. 2019 Sep 30;93(20):e00907-19. doi: 10.1128/JVI.00907-19. Print 2019 Oct 15. J Virol. 2019. PMID: 31375580 Free PMC article.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Kish K, McDonnell PA, Goldfarb V, Gao M, Metzler WJ, Langley DR, Bryson JW, Kiefer SE, Carpenter B, Kostich WA, Westphal RS, Sheriff S. Kish K, et al. Among authors: langley dr. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):768-74. doi: 10.1107/S1744309111017209. Epub 2011 Jun 30. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011. PMID: 21795790 Free PMC article.
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Sivaprakasam P, Wang Z, Meanwell NA, Khan JA, Langley DR, Johnson SR, Li G, Pendri A, Connolly TP, Gao M, Camac DM, Klakouski C, Zvyaga T, Cianci C, McAuliffe B, Ding B, Discotto L, Krystal MR, Jenkins S, Peese KM, Narasimhulu Naidu B. Sivaprakasam P, et al. Among authors: langley dr. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127531. doi: 10.1016/j.bmcl.2020.127531. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890685
Discovery of Isonicotinamides as Highly Selective, Brain Penetrable, and Orally Active Glycogen Synthase Kinase-3 Inhibitors.
Luo G, Chen L, Burton CR, Xiao H, Sivaprakasam P, Krause CM, Cao Y, Liu N, Lippy J, Clarke WJ, Snow K, Raybon J, Arora V, Pokross M, Kish K, Lewis HA, Langley DR, Macor JE, Dubowchik GM. Luo G, et al. Among authors: langley dr. J Med Chem. 2016 Feb 11;59(3):1041-51. doi: 10.1021/acs.jmedchem.5b01550. Epub 2016 Jan 22. J Med Chem. 2016. PMID: 26751161
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Peese KM, Naidu BN, Patel M, Li C, Langley DR, Terry B, Protack T, Gali V, Lin Z, Samanta HK, Zheng M, Jenkins S, Dicker IB, Krystal MR, Meanwell NA, Walker MA. Peese KM, et al. Among authors: langley dr. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126784. doi: 10.1016/j.bmcl.2019.126784. Epub 2019 Nov 9. Bioorg Med Chem Lett. 2020. PMID: 31761656
Biochemical and genetic characterizations of a novel human immunodeficiency virus type 1 inhibitor that blocks gp120-CD4 interactions.
Guo Q, Ho HT, Dicker I, Fan L, Zhou N, Friborg J, Wang T, McAuliffe BV, Wang HG, Rose RE, Fang H, Scarnati HT, Langley DR, Meanwell NA, Abraham R, Colonno RJ, Lin PF. Guo Q, et al. Among authors: langley dr. J Virol. 2003 Oct;77(19):10528-36. doi: 10.1128/jvi.77.19.10528-10536.2003. J Virol. 2003. PMID: 12970437 Free PMC article.
69 results