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Endocannabinoids exert CB1 receptor-mediated neuroprotective effects in models of neuronal damage induced by HIV-1 Tat protein.
Mol Cell Neurosci. 2017 Sep;83:92-102. doi: 10.1016/j.mcn.2017.07.003. Epub 2017 Jul 19.
Mol Cell Neurosci. 2017.
PMID: 28733129
Free PMC article.
Inhibitory Control Deficits Associated with Upregulation of CB1R in the HIV-1 Tat Transgenic Mouse Model of Hand.
Jacobs IR, Xu C, Hermes DJ, League AF, Xu C, Nath B, Jiang W, Niphakis MJ, Cravatt BF, Mackie K, Mukhopadhyay S, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.
Jacobs IR, et al.
J Neuroimmune Pharmacol. 2019 Dec;14(4):661-678. doi: 10.1007/s11481-019-09867-w. Epub 2019 Aug 1.
J Neuroimmune Pharmacol. 2019.
PMID: 31372820
Free PMC article.
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Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids.
Hermes DJ, Jacobs IR, Key MC, League AF, Yadav-Samudrala BJ, Xu C, McLane VD, Nass SR, Jiang W, Meeker RB, Ignatowska-Jankowska BM, Lichtman AH, Li Z, Wu Z, Yuan H, Knapp PE, Hauser KF, Fitting S.
Hermes DJ, et al. Among authors: jacobs ir.
J Neuroinflammation. 2020 Nov 18;17(1):345. doi: 10.1186/s12974-020-01971-6.
J Neuroinflammation. 2020.
PMID: 33208151
Free PMC article.
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Monoacylglycerol Lipase Inhibitor MJN110 Reduces Neuronal Hyperexcitability, Restores Dendritic Arborization Complexity, and Regulates Reward-Related Behavior in Presence of HIV-1 Tat.
League AF, Gorman BL, Hermes DJ, Johnson CT, Jacobs IR, Yadav-Samudrala BJ, Poklis JL, Niphakis MJ, Cravatt BF, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.
League AF, et al. Among authors: jacobs ir.
Front Neurol. 2021 Aug 16;12:651272. doi: 10.3389/fneur.2021.651272. eCollection 2021.
Front Neurol. 2021.
PMID: 34484091
Free PMC article.
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A helping HAND: therapeutic potential of MAGL inhibition against HIV-1-associated neuroinflammation.
League AF, Yadav-Samudrala BJ, Kolagani R, Cline CA, Jacobs IR, Manke J, Niphakis MJ, Cravatt BF, Lichtman AH, Ignatowska-Jankowska BM, Fitting S.
League AF, et al. Among authors: jacobs ir.
Front Immunol. 2024 May 21;15:1374301. doi: 10.3389/fimmu.2024.1374301. eCollection 2024.
Front Immunol. 2024.
PMID: 38835765
Free PMC article.
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