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Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.
Yeo A, Li L, Warren L, Aponte J, Fraser D, King K, Johansson K, Barnes A, MacPhee C, Davies R, Chissoe S, Tarka E, O'Donoghue ML, White HD, Wallentin L, Waterworth D. Yeo A, et al. Among authors: li l. PLoS One. 2017 Jul 28;12(7):e0182115. doi: 10.1371/journal.pone.0182115. eCollection 2017. PLoS One. 2017. PMID: 28753643 Free PMC article.
Lp-PLA2, scavenger receptor class B type I gene (SCARB1) rs10846744 variant, and cardiovascular disease.
Manichaikul A, Wang XQ, Li L, Erdmann J, Lettre G, Bis JC, Waterworth D, Cushman M, Jenny NS, Post WS, Palmas W, Tsai MY, Wallentin L, White H, Schunkert H, O'Donnell CJ, Herrington DM, Rich SS, O'Donoghue ML, Rodriguez A. Manichaikul A, et al. Among authors: li l. PLoS One. 2018 Oct 5;13(10):e0204352. doi: 10.1371/journal.pone.0204352. eCollection 2018. PLoS One. 2018. PMID: 30289950 Free PMC article. Clinical Trial.
Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway.
Ehm MG, Aponte JL, Chiano MN, Yerges-Armstrong LM, Johnson T, Barker JN, Cook SF, Gupta A, Hinds DA, Li L, Nelson MR, Simpson MA, Tian C, McCarthy LC, Rajpal DK, Waterworth DM. Ehm MG, et al. Among authors: li l. PLoS One. 2017 Nov 1;12(11):e0186405. doi: 10.1371/journal.pone.0186405. eCollection 2017. PLoS One. 2017. PMID: 29091937 Free PMC article.
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease.
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A, Chen Y, Varga TV, Yaghootkar H, Luan J, Zhao JH, Willems SM, Wessel J, Wang S, Maruthur N, Michailidou K, Pirie A, van der Lee SJ, Gillson C, Al Olama AA, Amouyel P, Arriola L, Arveiler D, Aviles-Olmos I, Balkau B, Barricarte A, Barroso I, Garcia SB, Bis JC, Blankenberg S, Boehnke M, Boeing H, Boerwinkle E, Borecki IB, Bork-Jensen J, Bowden S, Caldas C, Caslake M; CVD50 consortium; Cupples LA, Cruchaga C, Czajkowski J, den Hoed M, Dunn JA, Earl HM, Ehret GB, Ferrannini E, Ferrieres J, Foltynie T, Ford I, Forouhi NG, Gianfagna F, Gonzalez C, Grioni S, Hiller L, Jansson JH, Jørgensen ME, Jukema JW, Kaaks R, Kee F, Kerrison ND, Key TJ, Kontto J, Kote-Jarai Z, Kraja AT, Kuulasmaa K, Kuusisto J, Linneberg A, Liu C, Marenne G, Mohlke KL, Morris AP, Muir K, Müller-Nurasyid M, Munroe PB, Navarro C, Nielsen SF, Nilsson PM, Nordestgaard BG, Packard CJ, Palli D, Panico S, Peloso GM, Perola M, Peters A, Poole CJ, Quirós JR, Rolandsson O, Sacerdote C, Salomaa V, Sánchez MJ, Sattar N, Sharp SJ, Sims R, Slimani N, Smith JA, Thompson DJ, Trompet S, Tumino R, van der A DL, van der Schouw YT, Virtamo J, Walker … See abstract for full author list ➔ Scott RA, et al. Among authors: li l. Sci Transl Med. 2016 Jun 1;8(341):341ra76. doi: 10.1126/scitranslmed.aad3744. Sci Transl Med. 2016. PMID: 27252175 Free PMC article.
ADRB2 p.Thr164Ile association with hospitalization depends upon asthma severity.
Condreay LD, Chiano MN, Li L, Harris E, Fraser DJ, Meyers DA, Bleecker ER, Crim C, Stempel D, Yancey SW, Ghosh S. Condreay LD, et al. Among authors: li l. J Allergy Clin Immunol. 2019 May;143(5):1962-1965.e4. doi: 10.1016/j.jaci.2019.01.012. Epub 2019 Jan 23. J Allergy Clin Immunol. 2019. PMID: 30682460 Free article. Clinical Trial. No abstract available.
Jinlida for Diabetes Prevention in Impaired Glucose Tolerance and Multiple Metabolic Abnormalities: The FOCUS Randomized Clinical Trial.
Ji H, Zhao X, Chen X, Fang H, Gao H, Wei G, Zhang M, Kuang H, Yang B, Cai X, Su Y, Piao C, Zhao S, Li L, Sun W, Xu T, Xu Q, Fan Y, Ye J, Yao C, Shang M, Song G, Chen L, Zheng Q, Xiao X, Yan L, Lian F, Tong X, Jia Z; FOCUS Trial Committees and Investigators. Ji H, et al. Among authors: li l. JAMA Intern Med. 2024 Jun 3. doi: 10.1001/jamainternmed.2024.1190. Online ahead of print. JAMA Intern Med. 2024. PMID: 38829648
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