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Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.
Alhadj Ali M, Liu YF, Arif S, Tatovic D, Shariff H, Gibson VB, Yusuf N, Baptista R, Eichmann M, Petrov N, Heck S, Yang JHM, Tree TIM, Pujol-Autonell I, Yeo L, Baumard L, Stenson R, Howell A, Clark A, Boult Z, Powrie J, Adams L, Wong FS, Luzio S, Dunseath G, Green K, O'Keefe A, Bayly G, Thorogood N, Andrews R, Leech N, Joseph F, Nair S, Seal S, Cheung H, Beam C, Hills R, Peakman M, Dayan CM. Alhadj Ali M, et al. Among authors: arif s. Sci Transl Med. 2017 Aug 9;9(402):eaaf7779. doi: 10.1126/scitranslmed.aaf7779. Sci Transl Med. 2017. PMID: 28794283 Clinical Trial.
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
Skowera A, Ellis RJ, Varela-Calviño R, Arif S, Huang GC, Van-Krinks C, Zaremba A, Rackham C, Allen JS, Tree TI, Zhao M, Dayan CM, Sewell AK, Unger WW, Drijfhout JW, Ossendorp F, Roep BO, Peakman M. Skowera A, et al. Among authors: arif s. J Clin Invest. 2008 Oct;118(10):3390-402. doi: 10.1172/JCI35449. J Clin Invest. 2008. PMID: 18802479 Free PMC article.
Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study.
Thrower SL, James L, Hall W, Green KM, Arif S, Allen JS, Van-Krinks C, Lozanoska-Ochser B, Marquesini L, Brown S, Wong FS, Dayan CM, Peakman M. Thrower SL, et al. Among authors: arif s. Clin Exp Immunol. 2009 Feb;155(2):156-65. doi: 10.1111/j.1365-2249.2008.03814.x. Epub 2008 Nov 20. Clin Exp Immunol. 2009. PMID: 19040615 Free PMC article. Clinical Trial.
521 results