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Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy.
Wu R, Chang HC, Khechaduri A, Chawla K, Tran M, Chai X, Wagg C, Ghanefar M, Jiang X, Bayeva M, Gonzalez F, Lopaschuk G, Ardehali H. Wu R, et al. J Clin Invest. 2014 Nov;124(11):4795-806. doi: 10.1172/JCI76737. Epub 2014 Oct 20. J Clin Invest. 2014. PMID: 25329697 Free PMC article.
Cardiac Energy Metabolism in Heart Failure.
Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED. Lopaschuk GD, et al. Circ Res. 2021 May 14;128(10):1487-1513. doi: 10.1161/CIRCRESAHA.121.318241. Epub 2021 May 13. Circ Res. 2021. PMID: 33983836 Free PMC article. Review.
Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.
Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences. Taegtmeyer H, et al. Among authors: lopaschuk gd. Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Circ Res. 2016. PMID: 27012580 Free PMC article. Review.
Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function.
Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ. Jessen N, et al. Among authors: lopaschuk gd. Biochim Biophys Acta. 2010 Jul-Aug;1802(7-8):593-600. doi: 10.1016/j.bbadis.2010.04.008. Epub 2010 May 2. Biochim Biophys Acta. 2010. PMID: 20441792 Free PMC article.
Trimetazidine therapy prevents obesity-induced cardiomyopathy in mice.
Ussher JR, Fillmore N, Keung W, Mori J, Beker DL, Wagg CS, Jaswal JS, Lopaschuk GD. Ussher JR, et al. Among authors: lopaschuk gd. Can J Cardiol. 2014 Aug;30(8):940-4. doi: 10.1016/j.cjca.2014.04.023. Epub 2014 Apr 29. Can J Cardiol. 2014. PMID: 25064584
414 results