Hawse JR - Search Results

1

First-in-Human Phase I Study of the Tamoxifen Metabolite Z-Endoxifen in Women With Endocrine-Refractory Metastatic Breast Cancer.

Goetz MP, Suman VJ, Reid JM, Northfelt DW, Mahr MA, Ralya AT, Kuffel M, Buhrow SA, Safgren SL, McGovern RM, Black J, Dockter T, Haddad T, Erlichman C, Adjei AA, Visscher D, Chalmers ZR, Frampton G, Kipp BR, Liu MC, Hawse JR, Doroshow JH, Collins JM, Streicher H, Ames MM, Ingle JN. Goetz MP, et al. Among authors: hawse jr. J Clin Oncol. 2017 Oct 20;35(30):3391-3400. doi: 10.1200/JCO.2017.73.3246. Epub 2017 Aug 30. J Clin Oncol. 2017. PMID: 28854070 Free PMC article. Clinical Trial.

2

Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors.

Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Hawse JR, et al. J Cell Biochem. 2008 Feb 1;103(2):383-92. doi: 10.1002/jcb.21425. J Cell Biochem. 2008. PMID: 17541956 Free PMC article. Review.

3

Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain.

Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC. Hawse JR, et al. Mol Endocrinol. 2008 Jul;22(7):1579-95. doi: 10.1210/me.2007-0253. Epub 2008 May 15. Mol Endocrinol. 2008. PMID: 18483178 Free PMC article.

4

The tamoxifen metabolite, endoxifen, is a potent antiestrogen that targets estrogen receptor alpha for degradation in breast cancer cells.

Wu X, Hawse JR, Subramaniam M, Goetz MP, Ingle JN, Spelsberg TC. Wu X, et al. Among authors: hawse jr. Cancer Res. 2009 Mar 1;69(5):1722-7. doi: 10.1158/0008-5472.CAN-08-3933. Epub 2009 Feb 24. Cancer Res. 2009. PMID: 19244106

5

Functional role of KLF10 in multiple disease processes.

Subramaniam M, Hawse JR, Rajamannan NM, Ingle JN, Spelsberg TC. Subramaniam M, et al. Among authors: hawse jr. Biofactors. 2010 Jan-Feb;36(1):8-18. doi: 10.1002/biof.67. Biofactors. 2010. PMID: 20087894 Free PMC article. Review.

6

Coprescription of tamoxifen and medications that inhibit CYP2D6.

Sideras K, Ingle JN, Ames MM, Loprinzi CL, Mrazek DP, Black JL, Weinshilboum RM, Hawse JR, Spelsberg TC, Goetz MP. Sideras K, et al. Among authors: hawse jr. J Clin Oncol. 2010 Jun 1;28(16):2768-76. doi: 10.1200/JCO.2009.23.8931. Epub 2010 May 3. J Clin Oncol. 2010. PMID: 20439629 Free PMC article. Review.

7

Estrogen receptor-beta sensitizes breast cancer cells to the anti-estrogenic actions of endoxifen.

Wu X, Subramaniam M, Grygo SB, Sun Z, Negron V, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Wu X, et al. Among authors: hawse jr. Breast Cancer Res. 2011 Mar 10;13(2):R27. doi: 10.1186/bcr2844. Breast Cancer Res. 2011. PMID: 21392396 Free PMC article.

8

Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody.

Wu X, Subramaniam M, Negron V, Cicek M, Reynolds C, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC, Hawse JR. Wu X, et al. Among authors: hawse jr. J Cell Biochem. 2012 Feb;113(2):711-23. doi: 10.1002/jcb.23443. J Cell Biochem. 2012. PMID: 22095450 Free PMC article.

9

Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.

Liu M, Wang L, Bongartz T, Hawse JR, Markovic SN, Schaid DJ, Mushiroda T, Kubo M, Nakamura Y, Kamatani N, Goss PE, Ingle JN, Weinshilboum RM. Liu M, et al. Among authors: hawse jr. Breast Cancer Res. 2012 Mar 9;14(2):R41. doi: 10.1186/bcr3137. Breast Cancer Res. 2012. PMID: 22405131 Free PMC article.

10

Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens.

Hawse JR, Subramaniam M, Cicek M, Wu X, Gingery A, Grygo SB, Sun Z, Pitel KS, Lingle WL, Goetz MP, Ingle JN, Spelsberg TC. Hawse JR, et al. PLoS One. 2013;8(1):e54613. doi: 10.1371/journal.pone.0054613. Epub 2013 Jan 28. PLoS One. 2013. PMID: 23382923 Free PMC article.

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