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Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.
Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D. Burbulla LF, et al. Among authors: savas jn. Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7. Science. 2017. PMID: 28882997 Free PMC article.
Acetylation targets mutant huntingtin to autophagosomes for degradation.
Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Jeong H, et al. Among authors: savas jn. Cell. 2009 Apr 3;137(1):60-72. doi: 10.1016/j.cell.2009.03.018. Cell. 2009. PMID: 19345187 Free PMC article.
Global Analysis of Protein Expression of Inner Ear Hair Cells.
Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR 3rd, Ryan AF, Savas JN. Hickox AE, et al. Among authors: savas jn. J Neurosci. 2017 Feb 1;37(5):1320-1339. doi: 10.1523/JNEUROSCI.2267-16.2016. Epub 2016 Dec 30. J Neurosci. 2017. PMID: 28039372 Free PMC article.
Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity.
Ortega JA, Daley EL, Kour S, Samani M, Tellez L, Smith HS, Hall EA, Esengul YT, Tsai YH, Gendron TF, Donnelly CJ, Siddique T, Savas JN, Pandey UB, Kiskinis E. Ortega JA, et al. Among authors: savas jn. Neuron. 2020 Apr 8;106(1):90-107.e13. doi: 10.1016/j.neuron.2020.01.020. Epub 2020 Feb 13. Neuron. 2020. PMID: 32059759 Free PMC article.
Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission.
Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, Slutsky I, Farrow K, De Strooper B, de Wit J. Rice HC, et al. Among authors: savas jn. Science. 2019 Jan 11;363(6423):eaao4827. doi: 10.1126/science.aao4827. Science. 2019. PMID: 30630900 Free PMC article.
102 results