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Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.
Zahedi K, Barone S, Destefano-Shields C, Brooks M, Murray-Stewart T, Dunworth M, Li W, Doherty JR, Hall MA, Smith RD, Cleveland JL, Casero RA Jr, Soleimani M. Zahedi K, et al. Among authors: doherty jr. PLoS One. 2017 Sep 8;12(9):e0184570. doi: 10.1371/journal.pone.0184570. eCollection 2017. PLoS One. 2017. PMID: 28886181 Free PMC article.
Targeting lactate metabolism for cancer therapeutics.
Doherty JR, Cleveland JL. Doherty JR, et al. J Clin Invest. 2013 Sep;123(9):3685-92. doi: 10.1172/JCI69741. Epub 2013 Sep 3. J Clin Invest. 2013. PMID: 23999443 Free PMC article. Review.
Tristetraprolin impairs myc-induced lymphoma and abolishes the malignant state.
Rounbehler RJ, Fallahi M, Yang C, Steeves MA, Li W, Doherty JR, Schaub FX, Sanduja S, Dixon DA, Blackshear PJ, Cleveland JL. Rounbehler RJ, et al. Among authors: doherty jr. Cell. 2012 Aug 3;150(3):563-74. doi: 10.1016/j.cell.2012.06.033. Cell. 2012. PMID: 22863009 Free PMC article.
Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis.
Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, Kumar KG, Butler AA, Bannister TD, Hooper AT, Unsal-Kacmaz K, Roush WR, Cleveland JL. Doherty JR, et al. Cancer Res. 2014 Feb 1;74(3):908-20. doi: 10.1158/0008-5472.CAN-13-2034. Epub 2013 Nov 27. Cancer Res. 2014. PMID: 24285728 Free PMC article.
Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.
den Hollander J, Rimpi S, Doherty JR, Rudelius M, Buck A, Hoellein A, Kremer M, Graf N, Scheerer M, Hall MA, Goga A, von Bubnoff N, Duyster J, Peschel C, Cleveland JL, Nilsson JA, Keller U. den Hollander J, et al. Among authors: doherty jr. Blood. 2010 Sep 2;116(9):1498-505. doi: 10.1182/blood-2009-11-251074. Epub 2010 Jun 2. Blood. 2010. PMID: 20519624 Free PMC article.
61 results