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188 results

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A randomised, double-blind clinical phase II trial of the efficacy, safety, tolerability and pharmacokinetics of a single dose combination treatment with artefenomel and piperaquine in adults and children with uncomplicated Plasmodium falciparum malaria.
Macintyre F, Adoke Y, Tiono AB, Duong TT, Mombo-Ngoma G, Bouyou-Akotet M, Tinto H, Bassat Q, Issifou S, Adamy M, Demarest H, Duparc S, Leroy D, Laurijssens BE, Biguenet S, Kibuuka A, Tshefu AK, Smith M, Foster C, Leipoldt I, Kremsner PG, Phuc BQ, Ouedraogo A, Ramharter M; OZ-Piperaquine Study Group. Macintyre F, et al. Among authors: tshefu ak. BMC Med. 2017 Oct 9;15(1):181. doi: 10.1186/s12916-017-0940-3. BMC Med. 2017. PMID: 28988541 Free PMC article. Clinical Trial.
Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trial.
Tshefu AK, Gaye O, Kayentao K, Thompson R, Bhatt KM, Sesay SS, Bustos DG, Tjitra E, Bedu-Addo G, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L; Pyronaridine-artesunate Study Team. Tshefu AK, et al. Lancet. 2010 Apr 24;375(9724):1457-67. doi: 10.1016/S0140-6736(10)60322-4. Lancet. 2010. PMID: 20417857 Clinical Trial.
Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRC.
Onyamboko MA, Meshnick SR, Fleckenstein L, Koch MA, Atibu J, Lokomba V, Douoguih M, Hemingway-Foday J, Wesche D, Ryder RW, Bose C, Wright LL, Tshefu AK, Capparelli EV. Onyamboko MA, et al. Among authors: tshefu ak. Malar J. 2011 Feb 28;10:49. doi: 10.1186/1475-2875-10-49. Malar J. 2011. PMID: 21352601 Free PMC article.
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial.
Kayentao K, Doumbo OK, Pénali LK, Offianan AT, Bhatt KM, Kimani J, Tshefu AK, Kokolomami JH, Ramharter M, de Salazar PM, Tiono AB, Ouédraogo A, Bustos MD, Quicho F, Borghini-Fuhrer I, Duparc S, Shin CS, Fleckenstein L. Kayentao K, et al. Among authors: tshefu ak. Malar J. 2012 Oct 31;11:364. doi: 10.1186/1475-2875-11-364. Malar J. 2012. PMID: 23113947 Free PMC article. Clinical Trial.
Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®).
Tiono AB, Tinto H, Alao MJ, Meremikwu M, Tshefu A, Ogutu B, Ouedraogo A, Lingani M, Cousin M, Lefèvre G, Jain JP, Duparc S, Hamed K. Tiono AB, et al. Malar J. 2015 Apr 15;14:157. doi: 10.1186/s12936-015-0682-7. Malar J. 2015. PMID: 25886021 Free PMC article. Clinical Trial.
An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic Republic of Congo: the MATIAS study.
Ferrari G, Ntuku HM, Burri C, Tshefu AK, Duparc S, Hugo P, Mitembo DK, Ross A, Ngwala PL, Luwawu JN, Musafiri PN, Ngoie SE, Lengeler C. Ferrari G, et al. Among authors: tshefu ak. Malar J. 2015 May 30;14:226. doi: 10.1186/s12936-015-0732-1. Malar J. 2015. PMID: 26024661 Free PMC article. Clinical Trial.
A Phase 3, Double-Blind, Randomized Study of Arterolane Maleate-Piperaquine Phosphate vs Artemether-Lumefantrine for Falciparum Malaria in Adolescent and Adult Patients in Asia and Africa.
Toure OA, Valecha N, Tshefu AK, Thompson R, Krudsood S, Gaye O, Rao BHK, Sagara I, Bose TK, Mohanty S, Rao BS, Anvikar AR, Mwapasa V, Noedl H, Arora S, Roy A, Iyer SS, Sharma P, Saha N, Jalali RK; AM–PQP Study Team; Tiacoh L, Enosse S, Tangpukdee N, Kokolomami J, Ndiaye JL, Rao D, Yumva NN, Sidibe B, Mohanty R, Jha AC, Nyirenda M, Starzengruber P, Swoboda P. Toure OA, et al. Among authors: tshefu ak. Clin Infect Dis. 2016 Apr 15;62(8):964-971. doi: 10.1093/cid/ciw029. Epub 2016 Feb 21. Clin Infect Dis. 2016. PMID: 26908796 Free PMC article. Clinical Trial.
Assessment of Efficacy and Safety of Arterolane Maleate-Piperaquine Phosphate Dispersible Tablets in Comparison With Artemether-Lumefantrine Dispersible Tablets in Pediatric Patients With Acute Uncomplicated Plasmodium falciparum Malaria: A Phase 3, Randomized, Multicenter Trial in India and Africa.
Toure OA, Mwapasa V, Sagara I, Gaye O, Thompson R, Maheshwar AV, Mishra P, Behra N, Tshefu AK, Das RR, Anvikar AR, Sharma P, Roy A, Sharma SK, Nasa A, Jalali RK, Valecha N; Arterolane Maleate-Piperaquine Phosphate (AM-PQP) Study Team. Toure OA, et al. Among authors: tshefu ak. Clin Infect Dis. 2017 Oct 30;65(10):1711-1720. doi: 10.1093/cid/cix617. Clin Infect Dis. 2017. PMID: 29020247 Clinical Trial.
188 results