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A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.
Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A; WGS500 Consortium; Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC. Davies B, et al. Among authors: brown la. Hum Mol Genet. 2017 Oct 15;26(20):3869-3882. doi: 10.1093/hmg/ddx270. Hum Mol Genet. 2017. PMID: 29016847 Free PMC article.
Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.
Pritchett D, Jagannath A, Brown LA, Tam SK, Hasan S, Gatti S, Harrison PJ, Bannerman DM, Foster RG, Peirson SN. Pritchett D, et al. Among authors: brown la. PLoS One. 2015 May 7;10(5):e0125523. doi: 10.1371/journal.pone.0125523. eCollection 2015. PLoS One. 2015. PMID: 25950516 Free PMC article.
Light Input to the Mammalian Circadian Clock.
Dannerfjord AA, Brown LA, Foster RG, Peirson SN. Dannerfjord AA, et al. Among authors: brown la. Methods Mol Biol. 2021;2130:233-247. doi: 10.1007/978-1-0716-0381-9_18. Methods Mol Biol. 2021. PMID: 33284449
606 results