De Genst EJ - Search Results

1

Immunization with α-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model.

Villadiego J, Labrador-Garrido A, Franco JM, Leal-Lasarte M, De Genst EJ, Dobson CM, Pozo D, Toledo-Aral JJ, Roodveldt C. Villadiego J, et al. Among authors: de genst ej. Glia. 2018 Jan;66(1):191-205. doi: 10.1002/glia.23237. Epub 2017 Oct 11. Glia. 2018. PMID: 29024008

2

Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response.

Labrador-Garrido A, Cejudo-Guillén M, Daturpalli S, Leal MM, Klippstein R, De Genst EJ, Villadiego J, Toledo-Aral JJ, Dobson CM, Jackson SE, Pozo D, Roodveldt C. Labrador-Garrido A, et al. Among authors: de genst ej. FASEB J. 2016 Feb;30(2):564-77. doi: 10.1096/fj.15-275131. Epub 2015 Oct 6. FASEB J. 2016. PMID: 26443817

3

A rationally designed six-residue swap generates comparability in the aggregation behavior of α-synuclein and β-synuclein.

Roodveldt C, Andersson A, De Genst EJ, Labrador-Garrido A, Buell AK, Dobson CM, Tartaglia GG, Vendruscolo M. Roodveldt C, et al. Among authors: de genst ej. Biochemistry. 2012 Nov 6;51(44):8771-8. doi: 10.1021/bi300558q. Epub 2012 Oct 22. Biochemistry. 2012. PMID: 23003198

4

Chaperoned amyloid proteins for immune manipulation: α-Synuclein/Hsp70 shifts immunity toward a modulatory phenotype.

Labrador-Garrido A, Cejudo-Guillén M, Klippstein R, De Genst EJ, Tomas-Gallardo L, Leal MM, Villadiego J, Toledo-Aral JJ, Dobson CM, Pozo D, Roodveldt C. Labrador-Garrido A, et al. Among authors: de genst ej. Immun Inflamm Dis. 2014 Dec;2(4):226-38. doi: 10.1002/iid3.39. Epub 2014 Dec 5. Immun Inflamm Dis. 2014. PMID: 25866630 Free PMC article.

5

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

Chen SW, Drakulic S, Deas E, Ouberai M, Aprile FA, Arranz R, Ness S, Roodveldt C, Guilliams T, De-Genst EJ, Klenerman D, Wood NW, Knowles TP, Alfonso C, Rivas G, Abramov AY, Valpuesta JM, Dobson CM, Cremades N. Chen SW, et al. Among authors: de genst ej. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1994-2003. doi: 10.1073/pnas.1421204112. Epub 2015 Apr 8. Proc Natl Acad Sci U S A. 2015. PMID: 25855634 Free PMC article.

6

(1)H, (13)C and (15)N assignments of a camelid nanobody directed against human alpha-synuclein.

Vuchelen A, O'Day E, De Genst E, Pardon E, Wyns L, Dumoulin M, Dobson CM, Christodoulou J, Hsu ST. Vuchelen A, et al. Biomol NMR Assign. 2009 Dec;3(2):231-3. doi: 10.1007/s12104-009-9182-4. Biomol NMR Assign. 2009. PMID: 19763886 Free article.

7

Nanobodies as structural probes of protein misfolding and fibril formation.

De Genst E, Dobson CM. De Genst E, et al. Methods Mol Biol. 2012;911:533-58. doi: 10.1007/978-1-61779-968-6_34. Methods Mol Biol. 2012. PMID: 22886275 Review.

8

Antibodies and protein misfolding: From structural research tools to therapeutic strategies.

De Genst E, Messer A, Dobson CM. De Genst E, et al. Biochim Biophys Acta. 2014 Nov;1844(11):1907-1919. doi: 10.1016/j.bbapap.2014.08.016. Epub 2014 Sep 4. Biochim Biophys Acta. 2014. PMID: 25194824 Free article. Review.

9

Analysis of the native structure, stability and aggregation of biotinylated human lysozyme.

Ahn M, De Genst E, Kaminski Schierle GS, Erdelyi M, Kaminski CF, Dobson CM, Kumita JR. Ahn M, et al. PLoS One. 2012;7(11):e50192. doi: 10.1371/journal.pone.0050192. Epub 2012 Nov 16. PLoS One. 2012. PMID: 23166837 Free PMC article.

10

Structural Effects of Two Camelid Nanobodies Directed to Distinct C-Terminal Epitopes on α-Synuclein.

El-Turk F, Newby FN, De Genst E, Guilliams T, Sprules T, Mittermaier A, Dobson CM, Vendruscolo M. El-Turk F, et al. Biochemistry. 2016 Jun 7;55(22):3116-22. doi: 10.1021/acs.biochem.6b00149. Epub 2016 May 26. Biochemistry. 2016. PMID: 27096466

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