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TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways.
Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. Chen-Plotkin AS, et al. Among authors: gallagher md. J Neurosci. 2012 Aug 15;32(33):11213-27. doi: 10.1523/JNEUROSCI.0521-12.2012. J Neurosci. 2012. PMID: 22895706 Free PMC article.
TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.
Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, Frosch MP, Alafuzoff I, Antonell A, Bogdanovic N, Brooks W, Cairns NJ, Cooper-Knock J, Cotman C, Cras P, Cruts M, De Deyn PP, DeCarli C, Dobson-Stone C, Engelborghs S, Fox N, Galasko D, Gearing M, Gijselinck I, Grafman J, Hartikainen P, Hatanpaa KJ, Highley JR, Hodges J, Hulette C, Ince PG, Jin LW, Kirby J, Kofler J, Kril J, Kwok JB, Levey A, Lieberman A, Llado A, Martin JJ, Masliah E, McDermott CJ, McKee A, McLean C, Mead S, Miller CA, Miller J, Munoz DG, Murrell J, Paulson H, Piguet O, Rossor M, Sanchez-Valle R, Sano M, Schneider J, Silbert LC, Spina S, van der Zee J, Van Langenhove T, Warren J, Wharton SB, White CL 3rd, Woltjer RL, Trojanowski JQ, Lee VM, Van Deerlin V, Chen-Plotkin AS. Gallagher MD, et al. Acta Neuropathol. 2014 Mar;127(3):407-18. doi: 10.1007/s00401-013-1239-x. Epub 2014 Jan 19. Acta Neuropathol. 2014. PMID: 24442578 Free PMC article.
Lower plasma apolipoprotein A1 levels are found in Parkinson's disease and associate with apolipoprotein A1 genotype.
Swanson CR, Li K, Unger TL, Gallagher MD, Van Deerlin VM, Agarwal P, Leverenz J, Roberts J, Samii A, Gross RG, Hurtig H, Rick J, Weintraub D, Trojanowski JQ, Zabetian C, Chen-Plotkin AS. Swanson CR, et al. Among authors: gallagher md. Mov Disord. 2015 May;30(6):805-12. doi: 10.1002/mds.26022. Epub 2014 Sep 16. Mov Disord. 2015. PMID: 25227208 Free PMC article.
Common variant rs356182 near SNCA defines a Parkinson's disease endophenotype.
Cooper CA, Jain N, Gallagher MD, Weintraub D, Xie SX, Berlyand Y, Espay AJ, Quinn J, Edwards KL, Montine T, Van Deerlin VM, Trojanowski J, Zabetian CP, Chen-Plotkin AS. Cooper CA, et al. Among authors: gallagher md. Ann Clin Transl Neurol. 2016 Nov 25;4(1):15-25. doi: 10.1002/acn3.371. eCollection 2017 Jan. Ann Clin Transl Neurol. 2016. PMID: 28078311 Free PMC article.
The Post-GWAS Era: From Association to Function.
Gallagher MD, Chen-Plotkin AS. Gallagher MD, et al. Am J Hum Genet. 2018 May 3;102(5):717-730. doi: 10.1016/j.ajhg.2018.04.002. Am J Hum Genet. 2018. PMID: 29727686 Free PMC article. Review.
GPNMB confers risk for Parkinson's disease through interaction with α-synuclein.
Diaz-Ortiz ME, Seo Y, Posavi M, Carceles Cordon M, Clark E, Jain N, Charan R, Gallagher MD, Unger TL, Amari N, Skrinak RT, Davila-Rivera R, Brody EM, Han N, Zack R, Van Deerlin VM, Tropea TF, Luk KC, Lee EB, Weintraub D, Chen-Plotkin AS. Diaz-Ortiz ME, et al. Among authors: gallagher md. Science. 2022 Aug 19;377(6608):eabk0637. doi: 10.1126/science.abk0637. Epub 2022 Aug 19. Science. 2022. PMID: 35981040 Free PMC article.
Testing for Allele-specific Expression from Human Brain Samples.
Diaz-Ortiz ME, Jain N, Gallagher MD, Posavi M, Unger TL, Chen-Plotkin AS. Diaz-Ortiz ME, et al. Among authors: gallagher md. Bio Protoc. 2023 Oct 5;13(19):e4832. doi: 10.21769/BioProtoc.4832. eCollection 2023 Oct 5. Bio Protoc. 2023. PMID: 37817908 Free PMC article.
Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS.
Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, Sibert AG, Dhillon GK, Volsko C, Bartels CF, Adams DJ, Dutta R, Gallagher MD, Phu W, Kozlenkov A, Dracheva S, Scacheri PC, Tesar PJ, Corradin O. Factor DC, et al. Among authors: gallagher md. Cell. 2020 Apr 16;181(2):382-395.e21. doi: 10.1016/j.cell.2020.03.002. Epub 2020 Apr 3. Cell. 2020. PMID: 32246942 Free PMC article.
47 results