G protein-dependent signaling triggers a β-arrestin-scaffolded p70S6K/ rpS6 module that controls 5'TOP mRNA translation.
Tréfier A, Musnier A, Landomiel F, Bourquard T, Boulo T, Ayoub MA, León K, Bruneau G, Chevalier M, Durand G, Blache MC, Inoue A, Fontaine J, Gauthier C, Tesseraud S, Reiter E, Poupon A, Crépieux P.
Tréfier A, et al. Among authors: tesseraud s.
FASEB J. 2018 Mar;32(3):1154-1169. doi: 10.1096/fj.201700763R. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29084767
In agreement, FSH-induced rpS6 phosphorylation within the beta-arrestin scaffold was decreased in cells depleted of Galpha(s). Integration of the cooperative action of beta-arrestin and G proteins led to the translation of 5' oligopyrimidine track mRNA with high efficacy w …
In agreement, FSH-induced rpS6 phosphorylation within the beta-arrestin scaffold was decreased in cells depleted of Galpha(s). Integr …