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Inhibition of HIV-1 infection in humanized mice and metabolic stability of protein phosphatase-1-targeting small molecule 1E7-03.
Oncotarget. 2017 Aug 7;8(44):76749-76769. doi: 10.18632/oncotarget.19999. eCollection 2017 Sep 29.
Oncotarget. 2017.
PMID: 29100346
Free PMC article.
1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.
Ammosova T, Platonov M, Ivanov A, Kont YS, Kumari N, Kehn-Hall K, Jerebtsova M, Kulkarni AA, Uren A, Kovalskyy D, Nekhai S.
Ammosova T, et al. Among authors: kont ys.
Br J Pharmacol. 2014 Nov;171(22):5059-75. doi: 10.1111/bph.12863.
Br J Pharmacol. 2014.
PMID: 25073485
Free PMC article.
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Reactivation of latent HIV-1 provirus via targeting protein phosphatase-1.
Tyagi M, Iordanskiy S, Ammosova T, Kumari N, Smith K, Breuer D, Ilatovskiy AV, Kont YS, Ivanov A, Üren A, Kovalskyy D, Petukhov M, Kashanchi F, Nekhai S.
Tyagi M, et al. Among authors: kont ys.
Retrovirology. 2015 Jul 16;12:63. doi: 10.1186/s12977-015-0190-4.
Retrovirology. 2015.
PMID: 26178009
Free PMC article.
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A small molecule inhibitor of ETV1, YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.
Rahim S, Minas T, Hong SH, Justvig S, Çelik H, Kont YS, Han J, Kallarakal AT, Kong Y, Rudek MA, Brown ML, Kallakury B, Toretsky JA, Üren A.
Rahim S, et al. Among authors: kont ys.
PLoS One. 2014 Dec 5;9(12):e114260. doi: 10.1371/journal.pone.0114260. eCollection 2014.
PLoS One. 2014.
PMID: 25479232
Free PMC article.
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Ezrin Binds to DEAD-Box RNA Helicase DDX3 and Regulates Its Function and Protein Level.
Çelik H, Sajwan KP, Selvanathan SP, Marsh BJ, Pai AV, Kont YS, Han J, Minas TZ, Rahim S, Erkizan HV, Toretsky JA, Üren A.
Çelik H, et al. Among authors: kont ys.
Mol Cell Biol. 2015 Sep;35(18):3145-62. doi: 10.1128/MCB.00332-15. Epub 2015 Jul 6.
Mol Cell Biol. 2015.
PMID: 26149384
Free PMC article.
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Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box.
Çelik H, Hong SH, Colón-López DD, Han J, Kont YS, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Üren A.
Çelik H, et al. Among authors: kont ys.
Mol Cancer Ther. 2015 Nov;14(11):2497-507. doi: 10.1158/1535-7163.MCT-15-0511. Epub 2015 Sep 10.
Mol Cancer Ther. 2015.
PMID: 26358752
Free PMC article.
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Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Üren A, Adhikari S.
Kont YS, et al.
DNA Repair (Amst). 2016 Jul;43:38-47. doi: 10.1016/j.dnarep.2016.04.009. Epub 2016 May 7.
DNA Repair (Amst). 2016.
PMID: 27235629
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