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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ. Rai G, et al. Among authors: kuenstner ej. J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9. J Med Chem. 2017. PMID: 29120638 Free PMC article.
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
Furuya T, Shapiro AB, Comita-Prevoir J, Kuenstner EJ, Zhang J, Ribe SD, Chen A, Hines D, Moussa SH, Carter NM, Sylvester MA, Romero JAC, Vega CV, Sacco MD, Chen Y, O'Donnell JP, Durand-Reville TF, Miller AA, Tommasi RA. Furuya T, et al. Among authors: kuenstner ej. Bioorg Med Chem. 2020 Dec 15;28(24):115826. doi: 10.1016/j.bmc.2020.115826. Epub 2020 Oct 28. Bioorg Med Chem. 2020. PMID: 33160146
A Concise Approach to Paxilline Indole Diterpenes.
George DT, Kuenstner EJ, Pronin SV. George DT, et al. Among authors: kuenstner ej. J Am Chem Soc. 2015 Dec 16;137(49):15410-3. doi: 10.1021/jacs.5b11129. Epub 2015 Dec 7. J Am Chem Soc. 2015. PMID: 26593869 Free PMC article.
Functionality and prevalence of trehalose-based oligosaccharides as novel compatible solutes in ascospores of Neosartorya fischeri (Aspergillus fischeri) and other fungi.
Wyatt TT, van Leeuwen MR, Golovina EA, Hoekstra FA, Kuenstner EJ, Palumbo EA, Snyder NL, Visagie C, Verkennis A, Hallsworth JE, Wösten HA, Dijksterhuis J. Wyatt TT, et al. Among authors: kuenstner ej. Environ Microbiol. 2015 Feb;17(2):395-411. doi: 10.1111/1462-2920.12558. Epub 2014 Oct 22. Environ Microbiol. 2015. PMID: 25040129 Free PMC article.