Neckers LM - Search Results

1

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ. Rai G, et al. Among authors: neckers lm. J Med Chem. 2017 Nov 22;60(22):9184-9204. doi: 10.1021/acs.jmedchem.7b00941. Epub 2017 Nov 9. J Med Chem. 2017. PMID: 29120638 Free PMC article.

2

Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.

Neckers L. Neckers L. Curr Med Chem. 2003 May;10(9):733-9. doi: 10.2174/0929867033457818. Curr Med Chem. 2003. PMID: 12678776 Review.

3

Screening for inducers of kinase degradation.

Neckers L. Neckers L. Chem Biol. 2003 Jul;10(7):587-9. doi: 10.1016/s1074-5521(03)00151-0. Chem Biol. 2003. PMID: 12890531 Free article.

4

Curcumin is an inhibitor of p300 histone acetylatransferase.

Marcu MG, Jung YJ, Lee S, Chung EJ, Lee MJ, Trepel J, Neckers L. Marcu MG, et al. Med Chem. 2006 Mar;2(2):169-74. doi: 10.2174/157340606776056133. Med Chem. 2006. PMID: 16787365

5

Using natural product inhibitors to validate Hsp90 as a molecular target in cancer.

Neckers L. Neckers L. Curr Top Med Chem. 2006;6(11):1163-71. doi: 10.2174/156802606777811979. Curr Top Med Chem. 2006. PMID: 16842153 Review.

6

Update on Hsp90 inhibitors in clinical trial.

Kim YS, Alarcon SV, Lee S, Lee MJ, Giaccone G, Neckers L, Trepel JB. Kim YS, et al. Curr Top Med Chem. 2009;9(15):1479-92. doi: 10.2174/156802609789895728. Curr Top Med Chem. 2009. PMID: 19860730 Free PMC article. Review.

7

Methoxychalcone inhibitors of androgen receptor translocation and function.

Kim YS, Kumar V, Lee S, Iwai A, Neckers L, Malhotra SV, Trepel JB. Kim YS, et al. Bioorg Med Chem Lett. 2012 Mar 1;22(5):2105-9. doi: 10.1016/j.bmcl.2011.12.141. Epub 2012 Jan 21. Bioorg Med Chem Lett. 2012. PMID: 22310230 Free PMC article.

8

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M. Walton-Diaz A, et al. Future Med Chem. 2013 Jun;5(9):1059-71. doi: 10.4155/fmc.13.88. Future Med Chem. 2013. PMID: 23734688 Free PMC article. Review.

9

Synthesis and structure-activity relationship studies of novel dihydropyridones as androgen receptor modulators.

Pepe A, Pamment M, Kim YS, Lee S, Lee MJ, Beebe K, Filikov A, Neckers L, Trepel JB, Malhotra SV. Pepe A, et al. J Med Chem. 2013 Nov 14;56(21):8280-97. doi: 10.1021/jm301714s. Epub 2013 Oct 30. J Med Chem. 2013. PMID: 24044500 Free PMC article.

10

Synthesis of a stable and orally bioavailable englerin analogue.

Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Sulzmaier FJ, Ramos JW, Sourbier C, Neckers L, Figg WD, Beutler JA, Chain WJ. Fash DM, et al. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2641-4. doi: 10.1016/j.bmcl.2016.04.016. Epub 2016 Apr 8. Bioorg Med Chem Lett. 2016. PMID: 27107948 Free PMC article.

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