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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.
Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M. Anumala UR, et al. Among authors: murthy s. J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8. J Med Chem. 2017. PMID: 29155568
Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
Nathubhai A, Haikarainen T, Koivunen J, Murthy S, Koumanov F, Lloyd MD, Holman GD, Pihlajaniemi T, Tosh D, Lehtiö L, Threadgill MD. Nathubhai A, et al. Among authors: murthy s. J Med Chem. 2017 Jan 26;60(2):814-820. doi: 10.1021/acs.jmedchem.6b01574. Epub 2017 Jan 9. J Med Chem. 2017. PMID: 27983846 Free article.
2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.
Nkizinkiko Y, Desantis J, Koivunen J, Haikarainen T, Murthy S, Sancineto L, Massari S, Ianni F, Obaji E, Loza MI, Pihlajaniemi T, Brea J, Tabarrini O, Lehtiö L. Nkizinkiko Y, et al. Among authors: murthy s. Sci Rep. 2018 Jan 26;8(1):1680. doi: 10.1038/s41598-018-19872-3. Sci Rep. 2018. PMID: 29374194 Free PMC article.
Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
Waaler J, Leenders RGG, Sowa ST, Alam Brinch S, Lycke M, Nieczypor P, Aertssen S, Murthy S, Galera-Prat A, Damen E, Wegert A, Nazaré M, Lehtiö L, Krauss S. Waaler J, et al. Among authors: murthy s. J Med Chem. 2020 Jul 9;63(13):6834-6846. doi: 10.1021/acs.jmedchem.0c00208. Epub 2020 Jun 23. J Med Chem. 2020. PMID: 32511917 Free PMC article.
IceBear: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition.
Daniel E, Maksimainen MM, Smith N, Ratas V, Biterova E, Murthy SN, Rahman MT, Kiema TR, Sridhar S, Cordara G, Dalwani S, Venkatesan R, Prilusky J, Dym O, Lehtiö L, Koski MK, Ashton AW, Sussman JL, Wierenga RK. Daniel E, et al. Among authors: murthy sn. Acta Crystallogr D Struct Biol. 2021 Feb 1;77(Pt 2):151-163. doi: 10.1107/S2059798320015223. Epub 2021 Jan 26. Acta Crystallogr D Struct Biol. 2021. PMID: 33559605 Free PMC article.
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs.
Maksimainen MM, Murthy S, Sowa ST, Galera-Prat A, Rolina E, Heiskanen JP, Lehtiö L. Maksimainen MM, et al. Among authors: murthy s. Bioorg Med Chem. 2021 Dec 15;52:116511. doi: 10.1016/j.bmc.2021.116511. Epub 2021 Nov 10. Bioorg Med Chem. 2021. PMID: 34801828 Free article.
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II.
Leenders RGG, Brinch SA, Sowa ST, Amundsen-Isaksen E, Galera-Prat A, Murthy S, Aertssen S, Smits JN, Nieczypor P, Damen E, Wegert A, Nazaré M, Lehtiö L, Waaler J, Krauss S. Leenders RGG, et al. Among authors: murthy s. J Med Chem. 2021 Dec 23;64(24):17936-17949. doi: 10.1021/acs.jmedchem.1c01264. Epub 2021 Dec 8. J Med Chem. 2021. PMID: 34878777 Free PMC article.
2,353 results