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Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T. Takahashi H, et al. Among authors: morwick tm. J Med Chem. 2015 Feb 26;58(4):1669-90. doi: 10.1021/jm501185j. Epub 2015 Feb 11. J Med Chem. 2015. PMID: 25671290
Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase.
Goldberg DR, Butz T, Cardozo MG, Eckner RJ, Hammach A, Huang J, Jakes S, Kapadia S, Kashem M, Lukas S, Morwick TM, Panzenbeck M, Patel U, Pav S, Peet GW, Peterson JD, Prokopowicz AS 3rd, Snow RJ, Sellati R, Takahashi H, Tan J, Tschantz MA, Wang XJ, Wang Y, Wolak J, Xiong P, Moss N. Goldberg DR, et al. Among authors: morwick tm. J Med Chem. 2003 Apr 10;46(8):1337-49. doi: 10.1021/jm020446l. J Med Chem. 2003. PMID: 12672234
Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK).
Cywin CL, Zhao BP, McNeil DW, Hrapchak M, Prokopowicz AS, Goldberg DR, Morwick TM, Gao A, Jakes S, Kashem M, Magolda RL, Soll RM, Player MR, Bobko MA, Rinker J, DesJarlais RL, Winters MP. Cywin CL, et al. Among authors: morwick tm. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1415-8. doi: 10.1016/s0960-894x(03)00163-x. Bioorg Med Chem Lett. 2003. PMID: 12668002
11 results