Vanhaesebroeck B - Search Results

1

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B. Berenjeno IM, et al. Among authors: vanhaesebroeck b. Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4. Nat Commun. 2017. PMID: 29170395 Free PMC article.

2

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.

Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B. Ali K, et al. Among authors: vanhaesebroeck b. Nature. 2004 Oct 21;431(7011):1007-11. doi: 10.1038/nature02991. Nature. 2004. PMID: 15496927 Free article.

3

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

Foukas LC, Claret M, Pearce W, Okkenhaug K, Meek S, Peskett E, Sancho S, Smith AJ, Withers DJ, Vanhaesebroeck B. Foukas LC, et al. Among authors: vanhaesebroeck b. Nature. 2006 May 18;441(7091):366-70. doi: 10.1038/nature04694. Epub 2006 Apr 12. Nature. 2006. PMID: 16625210

4

Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

Cutillas PR, Khwaja A, Graupera M, Pearce W, Gharbi S, Waterfield M, Vanhaesebroeck B. Cutillas PR, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):8959-64. doi: 10.1073/pnas.0602101103. Epub 2006 Jun 2. Proc Natl Acad Sci U S A. 2006. PMID: 16751276 Free PMC article.

5

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.

Patton DT, Garden OA, Pearce WP, Clough LE, Monk CR, Leung E, Rowan WC, Sancho S, Walker LS, Vanhaesebroeck B, Okkenhaug K. Patton DT, et al. Among authors: vanhaesebroeck b. J Immunol. 2006 Nov 15;177(10):6598-602. doi: 10.4049/jimmunol.177.10.6598. J Immunol. 2006. PMID: 17082571

6

Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.

Ali K, Camps M, Pearce WP, Ji H, Rückle T, Kuehn N, Pasquali C, Chabert C, Rommel C, Vanhaesebroeck B. Ali K, et al. Among authors: vanhaesebroeck b. J Immunol. 2008 Feb 15;180(4):2538-44. doi: 10.4049/jimmunol.180.4.2538. J Immunol. 2008. PMID: 18250464 Free PMC article.

7

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Graupera M, et al. Among authors: vanhaesebroeck b. Nature. 2008 May 29;453(7195):662-6. doi: 10.1038/nature06892. Epub 2008 Apr 30. Nature. 2008. PMID: 18449193

8

PI3K regulatory subunits lose control in cancer.

Berenjeno IM, Vanhaesebroeck B. Berenjeno IM, et al. Among authors: vanhaesebroeck b. Cancer Cell. 2009 Dec 8;16(6):449-50. doi: 10.1016/j.ccr.2009.11.017. Cancer Cell. 2009. PMID: 19962660 Free article.

9

The emerging mechanisms of isoform-specific PI3K signalling.

Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, Bilanges B. Vanhaesebroeck B, et al. Nat Rev Mol Cell Biol. 2010 May;11(5):329-41. doi: 10.1038/nrm2882. Epub 2010 Apr 9. Nat Rev Mol Cell Biol. 2010. PMID: 20379207 Review.

10

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

Foukas LC, Berenjeno IM, Gray A, Khwaja A, Vanhaesebroeck B. Foukas LC, et al. Among authors: vanhaesebroeck b. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11381-6. doi: 10.1073/pnas.0906461107. Epub 2010 Jun 7. Proc Natl Acad Sci U S A. 2010. PMID: 20534549 Free PMC article.

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