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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism.
Bilanges B, Alliouachene S, Pearce W, Morelli D, Szabadkai G, Chung YL, Chicanne G, Valet C, Hill JM, Voshol PJ, Collinson L, Peddie C, Ali K, Ghazaly E, Rajeeve V, Trichas G, Srinivas S, Chaussade C, Salamon RS, Backer JM, Scudamore CL, Whitehead MA, Keaney EP, Murphy LO, Semple RK, Payrastre B, Tooze SA, Vanhaesebroeck B. Bilanges B, et al. Among authors: pearce w. Nat Commun. 2017 Nov 27;8(1):1804. doi: 10.1038/s41467-017-01969-4. Nat Commun. 2017. PMID: 29180704 Free PMC article.
Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity.
Alliouachene S, Bilanges B, Chicanne G, Anderson KE, Pearce W, Ali K, Valet C, Posor Y, Low PC, Chaussade C, Scudamore CL, Salamon RS, Backer JM, Stephens L, Hawkins PT, Payrastre B, Vanhaesebroeck B. Alliouachene S, et al. Among authors: pearce w. Cell Rep. 2015 Dec 1;13(9):1881-94. doi: 10.1016/j.celrep.2015.10.052. Epub 2015 Nov 19. Cell Rep. 2015. PMID: 26655903 Free PMC article.
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.
Berenjeno IM, Piñeiro R, Castillo SD, Pearce W, McGranahan N, Dewhurst SM, Meniel V, Birkbak NJ, Lau E, Sansregret L, Morelli D, Kanu N, Srinivas S, Graupera M, Parker VER, Montgomery KG, Moniz LS, Scudamore CL, Phillips WA, Semple RK, Clarke A, Swanton C, Vanhaesebroeck B. Berenjeno IM, et al. Among authors: pearce w. Nat Commun. 2017 Nov 24;8(1):1773. doi: 10.1038/s41467-017-02002-4. Nat Commun. 2017. PMID: 29170395 Free PMC article.
Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.
Foukas LC, Bilanges B, Bettedi L, Pearce W, Ali K, Sancho S, Withers DJ, Vanhaesebroeck B. Foukas LC, et al. Among authors: pearce w. EMBO Mol Med. 2013 Apr;5(4):563-71. doi: 10.1002/emmm.201201953. Epub 2013 Mar 11. EMBO Mol Med. 2013. PMID: 23483710 Free PMC article.
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner.
Madsen RR, Knox RG, Pearce W, Lopez S, Mahler-Araujo B, McGranahan N, Vanhaesebroeck B, Semple RK. Madsen RR, et al. Among authors: pearce w. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8380-8389. doi: 10.1073/pnas.1821093116. Epub 2019 Apr 4. Proc Natl Acad Sci U S A. 2019. PMID: 30948643 Free PMC article.
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response.
Ali K, Bilancio A, Thomas M, Pearce W, Gilfillan AM, Tkaczyk C, Kuehn N, Gray A, Giddings J, Peskett E, Fox R, Bruce I, Walker C, Sawyer C, Okkenhaug K, Finan P, Vanhaesebroeck B. Ali K, et al. Among authors: pearce w. Nature. 2004 Oct 21;431(7011):1007-11. doi: 10.1038/nature02991. Nature. 2004. PMID: 15496927 Free article.
606 results