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Inhibiting the Ca2+ Influx Induced by Human CSF.
Drews A, De S, Flagmeier P, Wirthensohn DC, Chen WH, Whiten DR, Rodrigues M, Vincke C, Muyldermans S, Paterson RW, Slattery CF, Fox NC, Schott JM, Zetterberg H, Dobson CM, Gandhi S, Klenerman D. Drews A, et al. Among authors: rodrigues m. Cell Rep. 2017 Dec 12;21(11):3310-3316. doi: 10.1016/j.celrep.2017.11.057. Cell Rep. 2017. PMID: 29241555 Free PMC article.
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer's disease progression.
De S, Whiten DR, Ruggeri FS, Hughes C, Rodrigues M, Sideris DI, Taylor CG, Aprile FA, Muyldermans S, Knowles TPJ, Vendruscolo M, Bryant C, Blennow K, Skoog I, Kern S, Zetterberg H, Klenerman D. De S, et al. Among authors: rodrigues m. Acta Neuropathol Commun. 2019 Jul 26;7(1):120. doi: 10.1186/s40478-019-0777-4. Acta Neuropathol Commun. 2019. PMID: 31349874 Free PMC article.
Optical Structural Analysis of Individual α-Synuclein Oligomers.
Varela JA, Rodrigues M, De S, Flagmeier P, Gandhi S, Dobson CM, Klenerman D, Lee SF. Varela JA, et al. Among authors: rodrigues m. Angew Chem Int Ed Engl. 2018 Apr 23;57(18):4886-4890. doi: 10.1002/anie.201710779. Epub 2018 Mar 23. Angew Chem Int Ed Engl. 2018. PMID: 29342318 Free PMC article.
Structure-specific amyloid precipitation in biofluids.
Rodrigues M, Bhattacharjee P, Brinkmalm A, Do DT, Pearson CM, De S, Ponjavic A, Varela JA, Kulenkampff K, Baudrexel I, Emin D, Ruggeri FS, Lee JE, Carr AR, Knowles TPJ, Zetterberg H, Snaddon TN, Gandhi S, Lee SF, Klenerman D. Rodrigues M, et al. Nat Chem. 2022 Sep;14(9):1045-1053. doi: 10.1038/s41557-022-00976-3. Epub 2022 Jul 7. Nat Chem. 2022. PMID: 35798951 Free article.
Mapping Surface Hydrophobicity of α-Synuclein Oligomers at the Nanoscale.
Lee JE, Sang JC, Rodrigues M, Carr AR, Horrocks MH, De S, Bongiovanni MN, Flagmeier P, Dobson CM, Wales DJ, Lee SF, Klenerman D. Lee JE, et al. Among authors: rodrigues m. Nano Lett. 2018 Dec 12;18(12):7494-7501. doi: 10.1021/acs.nanolett.8b02916. Epub 2018 Nov 7. Nano Lett. 2018. PMID: 30380895 Free PMC article.
Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson's disease pathogenesis.
Hughes CD, Choi ML, Ryten M, Hopkins L, Drews A, Botía JA, Iljina M, Rodrigues M, Gagliano SA, Gandhi S, Bryant C, Klenerman D. Hughes CD, et al. Among authors: rodrigues m. Acta Neuropathol. 2019 Jan;137(1):103-120. doi: 10.1007/s00401-018-1907-y. Epub 2018 Sep 17. Acta Neuropathol. 2019. PMID: 30225556 Free PMC article.
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Angelova PR, et al. Among authors: rodrigues m. Cell Death Differ. 2020 Oct;27(10):2781-2796. doi: 10.1038/s41418-020-0542-z. Epub 2020 Apr 27. Cell Death Differ. 2020. PMID: 32341450 Free PMC article.
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease.
Ludtmann MHR, Angelova PR, Horrocks MH, Choi ML, Rodrigues M, Baev AY, Berezhnov AV, Yao Z, Little D, Banushi B, Al-Menhali AS, Ranasinghe RT, Whiten DR, Yapom R, Dolt KS, Devine MJ, Gissen P, Kunath T, Jaganjac M, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Ludtmann MHR, et al. Among authors: rodrigues m. Nat Commun. 2018 Jun 12;9(1):2293. doi: 10.1038/s41467-018-04422-2. Nat Commun. 2018. PMID: 29895861 Free PMC article.
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation.
Angelova PR, Choi ML, Berezhnov AV, Horrocks MH, Hughes CD, De S, Rodrigues M, Yapom R, Little D, Dolt KS, Kunath T, Devine MJ, Gissen P, Shchepinov MS, Sylantyev S, Pavlov EV, Klenerman D, Abramov AY, Gandhi S. Angelova PR, et al. Among authors: rodrigues m. Cell Death Differ. 2020 Sep;27(9):2747. doi: 10.1038/s41418-020-0552-x. Cell Death Differ. 2020. PMID: 32409771 Free PMC article.
4,454 results