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A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.
Buch S, Stickel F, Trépo E, Way M, Herrmann A, Nischalke HD, Brosch M, Rosendahl J, Berg T, Ridinger M, Rietschel M, McQuillin A, Frank J, Kiefer F, Schreiber S, Lieb W, Soyka M, Semmo N, Aigner E, Datz C, Schmelz R, Brückner S, Zeissig S, Stephan AM, Wodarz N, Devière J, Clumeck N, Sarrazin C, Lammert F, Gustot T, Deltenre P, Völzke H, Lerch MM, Mayerle J, Eyer F, Schafmayer C, Cichon S, Nöthen MM, Nothnagel M, Ellinghaus D, Huse K, Franke A, Zopf S, Hellerbrand C, Moreno C, Franchimont D, Morgan MY, Hampe J. Buch S, et al. Nat Genet. 2015 Dec;47(12):1443-8. doi: 10.1038/ng.3417. Epub 2015 Oct 19. Nat Genet. 2015. PMID: 26482880 Free article.
Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3.
Quadri G, McQuillin A, Guerrini I, Thomson AD, Cherian R, Saini J, Ruparelia K, Lydall GJ, Ball D, Smith I, Way M, Kasiakogia-Worlley K, Patel S, Kottalgi G, Gunawardena P, Rao H, Hillman A, Douglas E, Qureshi SY, Reynolds G, Jauhar S, O'Kane A, Sharp S, Kandaswamy R, Dar K, Curtis D, Morgan MY, Gurling HM. Quadri G, et al. Psychiatr Genet. 2014 Jun;24(3):122-3. doi: 10.1097/YPG.0000000000000025. Psychiatr Genet. 2014. PMID: 24667528 Free PMC article. No abstract available.
Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population.
Way M, McQuillin A, Saini J, Ruparelia K, Lydall GJ, Guerrini I, Ball D, Smith I, Quadri G, Thomson AD, Kasiakogia-Worlley K, Cherian R, Gunwardena P, Rao H, Kottalgi G, Patel S, Hillman A, Douglas E, Qureshi SY, Reynolds G, Jauhar S, O'Kane A, Dedman A, Sharp S, Kandaswamy R, Dar K, Curtis D, Morgan MY, Gurling HM. Way M, et al. Addict Biol. 2015 May;20(3):594-604. doi: 10.1111/adb.12141. Epub 2014 Apr 16. Addict Biol. 2015. PMID: 24735490
The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder.
O'Brien NL, Way MJ, Kandaswamy R, Fiorentino A, Sharp SI, Quadri G, Alex J, Anjorin A, Ball D, Cherian R, Dar K, Gormez A, Guerrini I, Heydtmann M, Hillman A, Lankappa S, Lydall G, O'Kane A, Patel S, Quested D, Smith I, Thomson AD, Bass NJ, Morgan MY, Curtis D, McQuillin A. O'Brien NL, et al. Among authors: way mj. Psychiatr Genet. 2014 Dec;24(6):277-8. doi: 10.1097/YPG.0000000000000050. Psychiatr Genet. 2014. PMID: 25046171 Free PMC article. No abstract available.
46 results