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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies.
Sveen A, Bruun J, Eide PW, Eilertsen IA, Ramirez L, Murumägi A, Arjama M, Danielsen SA, Kryeziu K, Elez E, Tabernero J, Guinney J, Palmer HG, Nesbakken A, Kallioniemi O, Dienstmann R, Lothe RA. Sveen A, et al. Among authors: arjama m. Clin Cancer Res. 2018 Feb 15;24(4):794-806. doi: 10.1158/1078-0432.CCR-17-1234. Epub 2017 Dec 14. Clin Cancer Res. 2018. PMID: 29242316
Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness.
Karvonen H, Arjama M, Kaleva L, Niininen W, Barker H, Koivisto-Korander R, Tapper J, Pakarinen P, Lassus H, Loukovaara M, Bützow R, Kallioniemi O, Murumägi A, Ungureanu D. Karvonen H, et al. Among authors: arjama m. Cell Death Dis. 2020 Sep 23;11(9):790. doi: 10.1038/s41419-020-03009-4. Cell Death Dis. 2020. PMID: 32989221 Free PMC article.
E-cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models.
Bruun J, Eide PW, Bergsland CH, Bruck O, Svindland A, Arjama M, Välimäki K, Bjørnslett M, Guren MG, Kallioniemi O, Nesbakken A, Lothe RA, Pellinen T. Bruun J, et al. Among authors: arjama m. Mol Oncol. 2022 Jun;16(12):2312-2329. doi: 10.1002/1878-0261.13159. Epub 2021 Dec 26. Mol Oncol. 2022. PMID: 34890102 Free PMC article.
Multiomics characterization implicates PTK7 in ovarian cancer EMT and cell plasticity and offers strategies for therapeutic intervention.
Raivola J, Dini A, Karvonen H, Piki E, Salokas K, Niininen W, Kaleva L, Zhang K, Arjama M, Gudoityte G, Seashore-Ludlow B, Varjosalo M, Kallioniemi O, Hautaniemi S, Murumägi A, Ungureanu D. Raivola J, et al. Among authors: arjama m. Cell Death Dis. 2022 Aug 17;13(8):714. doi: 10.1038/s41419-022-05161-5. Cell Death Dis. 2022. PMID: 35977930 Free PMC article.
16 results