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Inhibition of EGFR, HER2, and HER3 signalling in patients with colorectal cancer wild-type for BRAF, PIK3CA, KRAS, and NRAS (FOCUS4-D): a phase 2-3 randomised trial.
Adams R, Brown E, Brown L, Butler R, Falk S, Fisher D, Kaplan R, Quirke P, Richman S, Samuel L, Seligmann J, Seymour M, Shiu KK, Wasan H, Wilson R, Maughan T; FOCUS4 Trial Investigators. Adams R, et al. Among authors: brown e, brown l. Lancet Gastroenterol Hepatol. 2018 Mar;3(3):162-171. doi: 10.1016/S2468-1253(17)30394-1. Epub 2017 Dec 16. Lancet Gastroenterol Hepatol. 2018. PMID: 29254887 Free PMC article. Clinical Trial.
Evaluating many treatments and biomarkers in oncology: a new design.
Kaplan R, Maughan T, Crook A, Fisher D, Wilson R, Brown L, Parmar M. Kaplan R, et al. Among authors: brown l. J Clin Oncol. 2013 Dec 20;31(36):4562-8. doi: 10.1200/JCO.2013.50.7905. Epub 2013 Nov 18. J Clin Oncol. 2013. PMID: 24248692 Free PMC article.
PROMIS--Prostate MR imaging study: A paired validating cohort study evaluating the role of multi-parametric MRI in men with clinical suspicion of prostate cancer.
El-Shater Bosaily A, Parker C, Brown LC, Gabe R, Hindley RG, Kaplan R, Emberton M, Ahmed HU; PROMIS Group. El-Shater Bosaily A, et al. Among authors: brown lc. Contemp Clin Trials. 2015 May;42:26-40. doi: 10.1016/j.cct.2015.02.008. Epub 2015 Mar 3. Contemp Clin Trials. 2015. PMID: 25749312 Free PMC article.
Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study.
Ahmed HU, El-Shater Bosaily A, Brown LC, Gabe R, Kaplan R, Parmar MK, Collaco-Moraes Y, Ward K, Hindley RG, Freeman A, Kirkham AP, Oldroyd R, Parker C, Emberton M; PROMIS study group. Ahmed HU, et al. Lancet. 2017 Feb 25;389(10071):815-822. doi: 10.1016/S0140-6736(16)32401-1. Epub 2017 Jan 20. Lancet. 2017. PMID: 28110982 Free article.
Diagnostic accuracy of the PROMIS study - Authors' reply.
Ahmed HU, Brown LC, Kaplan R, Parker C, Emberton M. Ahmed HU, et al. Lancet. 2017 Jul 22;390(10092):362. doi: 10.1016/S0140-6736(17)31595-7. Lancet. 2017. PMID: 28745603 Free article. No abstract available.
Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.
Parmar MK, Sydes MR, Cafferty FH, Choodari-Oskooei B, Langley RE, Brown L, Phillips PP, Spears MR, Rowley S, Kaplan R, James ND, Maughan T, Paton N, Royston PJ. Parmar MK, et al. Among authors: brown l. Clin Trials. 2017 Oct;14(5):451-461. doi: 10.1177/1740774517725697. Epub 2017 Aug 22. Clin Trials. 2017. PMID: 28830236 Free PMC article.
Multiparametric MRI to improve detection of prostate cancer compared with transrectal ultrasound-guided prostate biopsy alone: the PROMIS study.
Brown LC, Ahmed HU, Faria R, El-Shater Bosaily A, Gabe R, Kaplan RS, Parmar M, Collaco-Moraes Y, Ward K, Hindley RG, Freeman A, Kirkham A, Oldroyd R, Parker C, Bott S, Burns-Cox N, Dudderidge T, Ghei M, Henderson A, Persad R, Rosario DJ, Shergill I, Winkler M, Soares M, Spackman E, Sculpher M, Emberton M. Brown LC, et al. Health Technol Assess. 2018 Jul;22(39):1-176. doi: 10.3310/hta22390. Health Technol Assess. 2018. PMID: 30040065 Free PMC article.
7,617 results