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Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, Wu Q, Michaelraj KA, Miller TE, Hubert CG, Ryzhova M, Garzia L, Donovan L, Dombrowski S, Factor DC, Luu B, Valentim CLL, Gimple RC, Morton A, Kim L, Prager BC, Lee JJY, Wu X, Zuccaro J, Thompson Y, Holgado BL, Reimand J, Ke SQ, Tropper A, Lai S, Vijayarajah S, Doan S, Mahadev V, Miñan AF, Gröbner SN, Lienhard M, Zapatka M, Huang Z, Aldape KD, Carcaboso AM, Houghton PJ, Keir ST, Milde T, Witt H, Li Y, Li CJ, Bian XW, Jones DTW, Scott I, Singh SK, Huang A, Dirks PB, Bouffet E, Bradner JE, Ramaswamy V, Jabado N, Rutka JT, Northcott PA, Lupien M, Lichter P, Korshunov A, Scacheri PC, Pfister SM, Kool M, Taylor MD, Rich JN. Mack SC, et al. Among authors: scott i. Nature. 2018 Jan 4;553(7686):101-105. doi: 10.1038/nature25169. Epub 2017 Dec 20. Nature. 2018. PMID: 29258295 Free PMC article.
Enhancer-gene rewiring in the pathogenesis of Quebec platelet disorder.
Liang M, Soomro A, Tasneem S, Abatti LE, Alizada A, Yuan X, Uusküla-Reimand L, Antounians L, Alvi SA, Paterson AD, Rivard GÉ, Scott IC, Mitchell JA, Hayward CPM, Wilson MD. Liang M, et al. Blood. 2020 Dec 3;136(23):2679-2690. doi: 10.1182/blood.2020005394. Blood. 2020. PMID: 32663239 Free PMC article.
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Sharma P, Abbasi C, Lazic S, Teng ACT, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO. Sharma P, et al. Among authors: scott ic. Nat Commun. 2015 Sep 25;6:8391. doi: 10.1038/ncomms9391. Nat Commun. 2015. PMID: 26403541 Free article.
Anisotropic stress orients remodelling of mammalian limb bud ectoderm.
Lau K, Tao H, Liu H, Wen J, Sturgeon K, Sorfazlian N, Lazic S, Burrows JT, Wong MD, Li D, Deimling S, Ciruna B, Scott I, Simmons C, Henkelman RM, Williams T, Hadjantonakis AK, Fernandez-Gonzalez R, Sun Y, Hopyan S. Lau K, et al. Among authors: scott i. Nat Cell Biol. 2015 May;17(5):569-79. doi: 10.1038/ncb3156. Epub 2015 Apr 20. Nat Cell Biol. 2015. PMID: 25893915 Free PMC article.
Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.
van Eif VWW, Protze SI, Bosada FM, Yuan X, Sinha T, van Duijvenboden K, Ernault AC, Mohan RA, Wakker V, de Gier-de Vries C, Hooijkaas IB, Wilson MD, Verkerk AO, Bakkers J, Boukens BJ, Black BL, Scott IC, Christoffels VM. van Eif VWW, et al. Among authors: scott ic. Circ Res. 2020 Dec 4;127(12):1522-1535. doi: 10.1161/CIRCRESAHA.120.317054. Epub 2020 Oct 12. Circ Res. 2020. PMID: 33040635 Free PMC article.
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.
Lee SH, Hadipour-Lakmehsari S, Murthy HR, Gibb N, Miyake T, Teng ACT, Cosme J, Yu JC, Moon M, Lim S, Wong V, Liu P, Billia F, Fernandez-Gonzalez R, Stagljar I, Sharma P, Kislinger T, Scott IC, Gramolini AO. Lee SH, et al. Among authors: scott ic. Nat Commun. 2020 Feb 19;11(1):965. doi: 10.1038/s41467-019-14143-9. Nat Commun. 2020. PMID: 32075961 Free PMC article.
1,446 results