Connexin 43 gap junctions contribute to brain endothelial barrier hyperpermeability in familial cerebral cavernous malformations type III by modulating tight junction structure.
Johnson AM, Roach JP, Hu A, Stamatovic SM, Zochowski MR, Keep RF, Andjelkovic AV.
Johnson AM, et al. Among authors: hu a.
FASEB J. 2018 May;32(5):2615-2629. doi: 10.1096/fj.201700699R. Epub 2018 Jan 2.
FASEB J. 2018.
PMID: 29295866
Free PMC article.
We demonstrate that connexin 43 (Cx43), a gap junction (GJ) protein that is incorporated into the BBB junction complex, is up-regulated in lesions of a murine model of fCCM3. ...Overall, we demonstrate that Cx43 GJs are aberrantly increased in fCCM3 and regulate bar …
We demonstrate that connexin 43 (Cx43), a gap junction (GJ) protein that is incorporated into the BBB junction complex, is up-regulat …