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Saposins modulate human invariant Natural Killer T cells self-reactivity and facilitate lipid exchange with CD1d molecules during antigen presentation.
Salio M, Ghadbane H, Dushek O, Shepherd D, Cypen J, Gileadi U, Aichinger MC, Napolitani G, Qi X, van der Merwe PA, Wojno J, Veerapen N, Cox LR, Besra GS, Yuan W, Cresswell P, Cerundolo V. Salio M, et al. Among authors: shepherd d. Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):E4753-61. doi: 10.1073/pnas.1310050110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248359 Free PMC article.
Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.
Kurioka A, van Wilgenburg B, Javan RR, Hoyle R, van Tonder AJ, Harrold CL, Leng T, Howson LJ, Shepherd D, Cerundolo V, Brueggemann AB, Klenerman P. Kurioka A, et al. Among authors: shepherd d. J Infect Dis. 2018 Mar 5;217(6):988-999. doi: 10.1093/infdis/jix647. J Infect Dis. 2018. PMID: 29267892 Free PMC article.
Essential role for autophagy during invariant NKT cell development.
Salio M, Puleston DJ, Mathan TS, Shepherd D, Stranks AJ, Adamopoulou E, Veerapen N, Besra GS, Hollander GA, Simon AK, Cerundolo V. Salio M, et al. Among authors: shepherd d. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):E5678-87. doi: 10.1073/pnas.1413935112. Epub 2014 Dec 15. Proc Natl Acad Sci U S A. 2014. PMID: 25512546 Free PMC article.
Non-glycosidic compounds can stimulate both human and mouse iNKT cells.
Jukes JP, Gileadi U, Ghadbane H, Yu TF, Shepherd D, Cox LR, Besra GS, Cerundolo V. Jukes JP, et al. Among authors: shepherd d. Eur J Immunol. 2016 May;46(5):1224-34. doi: 10.1002/eji.201546114. Epub 2016 Mar 1. Eur J Immunol. 2016. PMID: 26873393 Free PMC article.
Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.
Timosenko E, Ghadbane H, Silk JD, Shepherd D, Gileadi U, Howson LJ, Laynes R, Zhao Q, Strausberg RL, Olsen LR, Taylor S, Buffa FM, Boyd R, Cerundolo V. Timosenko E, et al. Among authors: shepherd d. Cancer Res. 2016 Nov 1;76(21):6193-6204. doi: 10.1158/0008-5472.CAN-15-3502. Epub 2016 Sep 20. Cancer Res. 2016. PMID: 27651314 Free PMC article.
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation.
McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy BG, Schmidt RR, Reiter Y, Griffiths GM, van der Merwe PA, Besra GS, Jones EY, Batista FD, Cerundolo V. McCarthy C, et al. Among authors: shepherd d. J Exp Med. 2007 May 14;204(5):1131-44. doi: 10.1084/jem.20062342. Epub 2007 May 7. J Exp Med. 2007. PMID: 17485514 Free PMC article.
These data are consistent with previously described conformational changes between empty and loaded hCD1d molecules (Koch, M., V.S. Stronge, D. Shepherd, S.D. Gadola, B. Mathew, G. Ritter, A.R. Fersht, G.S. ...
These data are consistent with previously described conformational changes between empty and loaded hCD1d molecules (Koch, M., V.S. Stronge, …
Invariant natural killer T cells are not affected by lysosomal storage in patients with Niemann-Pick disease type C.
Speak AO, Platt N, Salio M, te Vruchte D, Smith DA, Shepherd D, Veerapen N, Besra GS, Yanjanin NM, Simmons L, Imrie J, Wraith JE, Lachmann RH, Hartung R, Runz H, Mengel E, Beck M, Hendriksz CJ, Porter FD, Cerundolo V, Platt FM. Speak AO, et al. Among authors: shepherd d. Eur J Immunol. 2012 Jul;42(7):1886-92. doi: 10.1002/eji.201141821. Epub 2012 Jun 14. Eur J Immunol. 2012. PMID: 22585405 Free PMC article.
868 results