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Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.
Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V. Solomon H, et al. Among authors: rotter v. Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18. Oncogene. 2018. PMID: 29343849 Free PMC article.
Mutant p53 gain-of-function in cancer.
Oren M, Rotter V. Oren M, et al. Among authors: rotter v. Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001107. doi: 10.1101/cshperspect.a001107. Cold Spring Harb Perspect Biol. 2010. PMID: 20182618 Free PMC article. Review.
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species.
Kalo E, Kogan-Sakin I, Solomon H, Bar-Nathan E, Shay M, Shetzer Y, Dekel E, Goldfinger N, Buganim Y, Stambolsky P, Goldstein I, Madar S, Rotter V. Kalo E, et al. Among authors: rotter v. J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86. doi: 10.1242/jcs.106815. Epub 2012 Aug 16. J Cell Sci. 2012. PMID: 22899716
Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.
Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M. Cooks T, et al. Among authors: rotter v. Cancer Cell. 2013 May 13;23(5):634-46. doi: 10.1016/j.ccr.2013.03.022. Cancer Cell. 2013. PMID: 23680148 Free PMC article.
p53 orchestrates between normal differentiation and cancer.
Rivlin N, Koifman G, Rotter V. Rivlin N, et al. Among authors: rotter v. Semin Cancer Biol. 2015 Jun;32:10-7. doi: 10.1016/j.semcancer.2013.12.006. Epub 2014 Jan 7. Semin Cancer Biol. 2015. PMID: 24406212 Review.
p53: the barrier to cancer stem cell formation.
Aloni-Grinstein R, Shetzer Y, Kaufman T, Rotter V. Aloni-Grinstein R, et al. Among authors: rotter v. FEBS Lett. 2014 Aug 19;588(16):2580-9. doi: 10.1016/j.febslet.2014.02.011. Epub 2014 Feb 19. FEBS Lett. 2014. PMID: 24560790 Free article.
Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.
Rivlin N, Katz S, Doody M, Sheffer M, Horesh S, Molchadsky A, Koifman G, Shetzer Y, Goldfinger N, Rotter V, Geiger T. Rivlin N, et al. Among authors: rotter v. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7006-11. doi: 10.1073/pnas.1320428111. Epub 2014 Apr 28. Proc Natl Acad Sci U S A. 2014. PMID: 24778235 Free PMC article.
306 results