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Page 1
Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers.
Solomon H, Dinowitz N, Pateras IS, Cooks T, Shetzer Y, Molchadsky A, Charni M, Rabani S, Koifman G, Tarcic O, Porat Z, Kogan-Sakin I, Goldfinger N, Oren M, Harris CC, Gorgoulis VG, Rotter V. Solomon H, et al. Among authors: shetzer y. Oncogene. 2018 Mar;37(12):1669-1684. doi: 10.1038/s41388-017-0060-8. Epub 2018 Jan 18. Oncogene. 2018. PMID: 29343849 Free PMC article.
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species.
Kalo E, Kogan-Sakin I, Solomon H, Bar-Nathan E, Shay M, Shetzer Y, Dekel E, Goldfinger N, Buganim Y, Stambolsky P, Goldstein I, Madar S, Rotter V. Kalo E, et al. Among authors: shetzer y. J Cell Sci. 2012 Nov 15;125(Pt 22):5578-86. doi: 10.1242/jcs.106815. Epub 2012 Aug 16. J Cell Sci. 2012. PMID: 22899716
Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.
Rivlin N, Katz S, Doody M, Sheffer M, Horesh S, Molchadsky A, Koifman G, Shetzer Y, Goldfinger N, Rotter V, Geiger T. Rivlin N, et al. Among authors: shetzer y. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7006-11. doi: 10.1073/pnas.1320428111. Epub 2014 Apr 28. Proc Natl Acad Sci U S A. 2014. PMID: 24778235 Free PMC article.
The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele.
Shetzer Y, Kagan S, Koifman G, Sarig R, Kogan-Sakin I, Charni M, Kaufman T, Zapatka M, Molchadsky A, Rivlin N, Dinowitz N, Levin S, Landan G, Goldstein I, Goldfinger N, Pe'er D, Radlwimmer B, Lichter P, Rotter V, Aloni-Grinstein R. Shetzer Y, et al. Cell Death Differ. 2014 Sep;21(9):1419-31. doi: 10.1038/cdd.2014.57. Epub 2014 May 16. Cell Death Differ. 2014. PMID: 24832469 Free PMC article.
p53: the barrier to cancer stem cell formation.
Aloni-Grinstein R, Shetzer Y, Kaufman T, Rotter V. Aloni-Grinstein R, et al. Among authors: shetzer y. FEBS Lett. 2014 Aug 19;588(16):2580-9. doi: 10.1016/j.febslet.2014.02.011. Epub 2014 Feb 19. FEBS Lett. 2014. PMID: 24560790 Free article.
p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition.
Brosh R, Assia-Alroy Y, Molchadsky A, Bornstein C, Dekel E, Madar S, Shetzer Y, Rivlin N, Goldfinger N, Sarig R, Rotter V. Brosh R, et al. Among authors: shetzer y. Cell Death Differ. 2013 Feb;20(2):312-20. doi: 10.1038/cdd.2012.125. Epub 2012 Sep 21. Cell Death Differ. 2013. PMID: 22996684 Free PMC article.