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Impact of a five-dimensional framework on R&D productivity at AstraZeneca.
Morgan P, Brown DG, Lennard S, Anderton MJ, Barrett JC, Eriksson U, Fidock M, Hamrén B, Johnson A, March RE, Matcham J, Mettetal J, Nicholls DJ, Platz S, Rees S, Snowden MA, Pangalos MN. Morgan P, et al. Among authors: brown dg. Nat Rev Drug Discov. 2018 Mar;17(3):167-181. doi: 10.1038/nrd.2017.244. Epub 2018 Jan 19. Nat Rev Drug Discov. 2018. PMID: 29348681
ESKAPEing the labyrinth of antibacterial discovery.
Tommasi R, Brown DG, Walkup GK, Manchester JI, Miller AA. Tommasi R, et al. Among authors: brown dg. Nat Rev Drug Discov. 2015 Aug;14(8):529-42. doi: 10.1038/nrd4572. Epub 2015 Jul 3. Nat Rev Drug Discov. 2015. PMID: 26139286 Review.
Expanding the medicinal chemistry synthetic toolbox.
Boström J, Brown DG, Young RJ, Keserü GM. Boström J, et al. Among authors: brown dg. Nat Rev Drug Discov. 2018 Oct;17(10):709-727. doi: 10.1038/nrd.2018.116. Epub 2018 Aug 24. Nat Rev Drug Discov. 2018. PMID: 30140018 Review.
Stuck in a rut with old chemistry.
Boström J, Brown DG. Boström J, et al. Among authors: brown dg. Drug Discov Today. 2016 May;21(5):701-3. doi: 10.1016/j.drudis.2016.02.017. Epub 2016 Mar 3. Drug Discov Today. 2016. PMID: 26945942 No abstract available.
Structural insight into allosteric modulation of protease-activated receptor 2.
Cheng RKY, Fiez-Vandal C, Schlenker O, Edman K, Aggeler B, Brown DG, Brown GA, Cooke RM, Dumelin CE, Doré AS, Geschwindner S, Grebner C, Hermansson NO, Jazayeri A, Johansson P, Leong L, Prihandoko R, Rappas M, Soutter H, Snijder A, Sundström L, Tehan B, Thornton P, Troast D, Wiggin G, Zhukov A, Marshall FH, Dekker N. Cheng RKY, et al. Among authors: brown ga, brown dg. Nature. 2017 May 4;545(7652):112-115. doi: 10.1038/nature22309. Epub 2017 Apr 26. Nature. 2017. PMID: 28445455
Expanding the medicinal chemistry synthetic toolbox.
Boström J, Brown DG, Young RJ, Keserü GM. Boström J, et al. Among authors: brown dg. Nat Rev Drug Discov. 2018 Nov 28;17(12):922. doi: 10.1038/nrd.2018.217. Nat Rev Drug Discov. 2018. PMID: 30482954
392 results