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Interaction between polymorphisms in aspirin metabolic pathways, regular aspirin use and colorectal cancer risk: A case-control study in unselected white European populations.
Sheth H, Northwood E, Ulrich CM, Scherer D, Elliott F, Barrett JH, Forman D, Wolf CR, Smith G, Jackson MS, Santibanez-Koref M, Haile R, Casey G, Jenkins M, Win AK, Hopper JL, Marchand LL, Lindor NM, Thibodeau SN, Potter JD, Burn J, Bishop DT. Sheth H, et al. Among authors: smith g. PLoS One. 2018 Feb 9;13(2):e0192223. doi: 10.1371/journal.pone.0192223. eCollection 2018. PLoS One. 2018. PMID: 29425227 Free PMC article.
Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.
Lightfoot TJ, Barrett JH, Bishop T, Northwood EL, Smith G, Wilkie MJ, Steele RJ, Carey FA, Key TJ, Wolf R, Forman D. Lightfoot TJ, et al. Among authors: smith g. Cancer Epidemiol Biomarkers Prev. 2008 Sep;17(9):2421-30. doi: 10.1158/1055-9965.EPI-08-0058. Epub 2008 Aug 14. Cancer Epidemiol Biomarkers Prev. 2008. PMID: 18703816
No evidence that polymorphisms in CYP2C8, CYP2C9, UGT1A6, PPARdelta and PPARgamma act as modifiers of the protective effect of regular NSAID use on the risk of colorectal carcinoma.
McGreavey LE, Turner F, Smith G, Boylan K, Timothy Bishop D, Forman D, Roland Wolf C, Barrett JH; Colorectal Cancer Study Group. McGreavey LE, et al. Among authors: smith g. Pharmacogenet Genomics. 2005 Oct;15(10):713-21. doi: 10.1097/01.fpc.0000174786.85238.63. Pharmacogenet Genomics. 2005. PMID: 16141797
Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer.
Timofeeva MN, Kinnersley B, Farrington SM, Whiffin N, Palles C, Svinti V, Lloyd A, Gorman M, Ooi LY, Hosking F, Barclay E, Zgaga L, Dobbins S, Martin L, Theodoratou E, Broderick P, Tenesa A, Smillie C, Grimes G, Hayward C, Campbell A, Porteous D, Deary IJ, Harris SE, Northwood EL, Barrett JH, Smith G, Wolf R, Forman D, Morreau H, Ruano D, Tops C, Wijnen J, Schrumpf M, Boot A, Vasen HF, Hes FJ, van Wezel T, Franke A, Lieb W, Schafmayer C, Hampe J, Buch S, Propping P, Hemminki K, Försti A, Westers H, Hofstra R, Pinheiro M, Pinto C, Teixeira M, Ruiz-Ponte C, Fernández-Rozadilla C, Carracedo A, Castells A, Castellví-Bel S, Campbell H, Bishop DT, Tomlinson IP, Dunlop MG, Houlston RS. Timofeeva MN, et al. Among authors: smith g. Sci Rep. 2015 Nov 10;5:16286. doi: 10.1038/srep16286. Sci Rep. 2015. PMID: 26553438 Free PMC article.
Cytochrome P450 CYP2D6.
Wolf CR, Smith G. Wolf CR, et al. Among authors: smith g. IARC Sci Publ. 1999;(148):209-29. IARC Sci Publ. 1999. PMID: 10493260 Review.
Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.
Sachse C, Bhambra U, Smith G, Lightfoot TJ, Barrett JH, Scollay J, Garner RC, Boobis AR, Wolf CR, Gooderham NJ; Colorectal Cancer Study Group. Sachse C, et al. Among authors: smith g. Br J Clin Pharmacol. 2003 Jan;55(1):68-76. doi: 10.1046/j.1365-2125.2003.01733.x. Br J Clin Pharmacol. 2003. PMID: 12534642 Free PMC article.
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