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989 results

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Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade.
Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Hyman JM, et al. Among authors: chen jk. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14132-7. doi: 10.1073/pnas.0907134106. Epub 2009 Aug 5. Proc Natl Acad Sci U S A. 2009. PMID: 19666565 Free PMC article.
A crucial requirement for Hedgehog signaling in small cell lung cancer.
Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. Park KS, et al. Among authors: chen jk. Nat Med. 2011 Oct 9;17(11):1504-8. doi: 10.1038/nm.2473. Nat Med. 2011. PMID: 21983857 Free PMC article.
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein.
Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Firestone AJ, et al. Among authors: chen jk. Nature. 2012 Mar 18;484(7392):125-9. doi: 10.1038/nature10936. Nature. 2012. PMID: 22425997 Free PMC article.
Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity.
See SK, Hoogendoorn S, Chung AH, Ye F, Steinman JB, Sakata-Kato T, Miller RM, Cupido T, Zalyte R, Carter AP, Nachury MV, Kapoor TM, Chen JK. See SK, et al. Among authors: chen jk. ACS Chem Biol. 2016 Jan 15;11(1):53-60. doi: 10.1021/acschembio.5b00895. Epub 2015 Nov 11. ACS Chem Biol. 2016. PMID: 26555042 Free PMC article.
An inducible long noncoding RNA amplifies DNA damage signaling.
Schmitt AM, Garcia JT, Hung T, Flynn RA, Shen Y, Qu K, Payumo AY, Peres-da-Silva A, Broz DK, Baum R, Guo S, Chen JK, Attardi LD, Chang HY. Schmitt AM, et al. Among authors: chen jk. Nat Genet. 2016 Nov;48(11):1370-1376. doi: 10.1038/ng.3673. Epub 2016 Sep 26. Nat Genet. 2016. PMID: 27668660 Free PMC article.
Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
Steinman JB, Santarossa CC, Miller RM, Yu LS, Serpinskaya AS, Furukawa H, Morimoto S, Tanaka Y, Nishitani M, Asano M, Zalyte R, Ondrus AE, Johnson AG, Ye F, Nachury MV, Fukase Y, Aso K, Foley MA, Gelfand VI, Chen JK, Carter AP, Kapoor TM. Steinman JB, et al. Among authors: chen jk. Elife. 2017 May 19;6:e25174. doi: 10.7554/eLife.25174. Elife. 2017. PMID: 28524820 Free PMC article.
989 results