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An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort.
Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. Geng X, et al. Among authors: an p. J Lipid Res. 2018 Apr;59(4):722-729. doi: 10.1194/jlr.P080333. Epub 2018 Feb 20. J Lipid Res. 2018. PMID: 29463568 Free PMC article.
In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therapy in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort using an exome-wide sequencing-based association stud …
In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) …
An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids.
Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC, Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I, Province MA, Mitchell BD, Arnett DK, Zhi D. Geng X, et al. Among authors: an p. Front Genet. 2019 Feb 26;10:158. doi: 10.3389/fgene.2019.00158. eCollection 2019. Front Genet. 2019. PMID: 30863429 Free PMC article.
In gene-based tests, we found statistically significant associations between ITGA7 (P = 1.77E-07) and SLCO2A1 (P = 7.18E-07) and triglycerides, as well as between POT1 (P = 3.00E-07) and low-density lipoprotein cholesterol. In another independent replication …
In gene-based tests, we found statistically significant associations between ITGA7 (P = 1.77E-07) and SLCO2A1 (P = 7.18E-07) a …
WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake.
Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK, Straka RJ, Province MA, An P, Borecki IB, Tucker KL, Ordovás JM. Lai CQ, et al. Among authors: an p. Obesity (Silver Spring). 2009 Mar;17(3):593-600. doi: 10.1038/oby.2008.561. Epub 2008 Dec 18. Obesity (Silver Spring). 2009. PMID: 19238144 Free PMC article.
Adipose (adp) is an obesity gene in Drosophila and mice with crucial functions in fat metabolism. ...Given the high frequency of the major alleles in both populations, we suggest that WDTC1 variation may be an important risk factor contributing to obesity in these p …
Adipose (adp) is an obesity gene in Drosophila and mice with crucial functions in fat metabolism. ...Given the high frequency of the …
Genetic variants at the PDZ-interacting domain of the scavenger receptor class B type I interact with diet to influence the risk of metabolic syndrome in obese men and women.
Junyent M, Arnett DK, Tsai MY, Kabagambe EK, Straka RJ, Province M, An P, Lai CQ, Parnell LD, Shen J, Lee YC, Borecki I, Ordovás JM. Junyent M, et al. Among authors: an p. J Nutr. 2009 May;139(5):842-8. doi: 10.3945/jn.108.101196. Epub 2009 Mar 25. J Nutr. 2009. PMID: 19321583 Free PMC article.
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate.
Shen J, Arnett DK, Parnell LD, Lai CQ, Straka RJ, Hopkins PN, An P, Feitosa MF, Ordovás JM. Shen J, et al. Among authors: an p. J Cardiovasc Pharmacol. 2012 Mar;59(3):254-9. doi: 10.1097/FJC.0b013e31823de86b. J Cardiovasc Pharmacol. 2012. PMID: 22075751 Free PMC article. Clinical Trial.
INTRODUCTION: CYP7A1 encodes cholesterol 7alpha-hydroxylase, an enzyme crucial to cholesterol homeostasis. Its transcriptional activity is downregulated by fenofibrate. ...Individuals homozygous for the common T allele of m204T>G single nuclear polymorphism displayed bo …
INTRODUCTION: CYP7A1 encodes cholesterol 7alpha-hydroxylase, an enzyme crucial to cholesterol homeostasis. Its transcriptional activi …
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response.
An P, Straka RJ, Pollin TI, Feitosa MF, Wojczynski MK, Daw EW, O'Connell JR, Gibson Q, Ryan KA, Hopkins PN, Tsai MY, Lai CQ, Province MA, Ordovas JM, Shuldiner AR, Arnett DK, Borecki IB. An P, et al. Hum Genet. 2014 Jul;133(7):919-30. doi: 10.1007/s00439-014-1435-3. Epub 2014 Mar 7. Hum Genet. 2014. PMID: 24604477 Free PMC article.
The best association signal was found in a tri-genic region at RHOQ-PIGF-CRIPT for baseline NHDL (lead SNP rs6544903, discovery p = 7e-7, MAF = 2 %; validation p = 6e-4 at 0.1 kb upstream neighboring SNP rs3768725, and 5e-4 at 0.7 kb downstream neighboring SNP rs673 …
The best association signal was found in a tri-genic region at RHOQ-PIGF-CRIPT for baseline NHDL (lead SNP rs6544903, discovery p = 7 …
Salivary AMY1 Copy Number Variation Modifies Age-Related Type 2 Diabetes Risk.
Liu Y, Smith CE, Parnell LD, Lee YC, An P, Straka RJ, Tiwari HK, Wood AC, Kabagambe EK, Hidalgo B, Hopkins PN, Province MA, Arnett DK, Tucker KL, Ordovas JM, Lai CQ. Liu Y, et al. Among authors: an p. Clin Chem. 2020 May 1;66(5):718-726. doi: 10.1093/clinchem/hvaa072. Clin Chem. 2020. PMID: 32337541 Free PMC article.
922 results