The antimicrobial drug pyrimethamine inhibits STAT3 transcriptional activity by targeting the enzyme dihydrofolate reductase.
Heppler LN, Attarha S, Persaud R, Brown JI, Wang P, Petrova B, Tošić I, Burton FB, Flamand Y, Walker SR, Yeh JE, Zubarev RA, Gaetani M, Kanarek N, Page BDG, Frank DA.
Heppler LN, et al. Among authors: petrova b.
J Biol Chem. 2022 Feb;298(2):101531. doi: 10.1016/j.jbc.2021.101531. Epub 2021 Dec 23.
J Biol Chem. 2022.
PMID: 34953855
Free PMC article.