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Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair.
Elife. 2018 Feb 28;7:e32692. doi: 10.7554/eLife.32692.
Elife. 2018.
PMID: 29488881
Free PMC article.
DNA polymerase ε and its roles in genome stability.
Henninger EE, Pursell ZF.
Henninger EE, et al.
IUBMB Life. 2014 May;66(5):339-51. doi: 10.1002/iub.1276. Epub 2014 May 24.
IUBMB Life. 2014.
PMID: 24861832
Free article.
Review.
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Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
Shlien A, Campbell BB, de Borja R, Alexandrov LB, Merico D, Wedge D, Van Loo P, Tarpey PS, Coupland P, Behjati S, Pollett A, Lipman T, Heidari A, Deshmukh S, Avitzur N, Meier B, Gerstung M, Hong Y, Merino DM, Ramakrishna M, Remke M, Arnold R, Panigrahi GB, Thakkar NP, Hodel KP, Henninger EE, Göksenin AY, Bakry D, Charames GS, Druker H, Lerner-Ellis J, Mistry M, Dvir R, Grant R, Elhasid R, Farah R, Taylor GP, Nathan PC, Alexander S, Ben-Shachar S, Ling SC, Gallinger S, Constantini S, Dirks P, Huang A, Scherer SW, Grundy RG, Durno C, Aronson M, Gartner A, Meyn MS, Taylor MD, Pursell ZF, Pearson CE, Malkin D, Futreal PA, Stratton MR, Bouffet E, Hawkins C, Campbell PJ, Tabori U; Biallelic Mismatch Repair Deficiency Consortium.
Shlien A, et al. Among authors: henninger ee.
Nat Genet. 2015 Mar;47(3):257-62. doi: 10.1038/ng.3202. Epub 2015 Feb 2.
Nat Genet. 2015.
PMID: 25642631
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Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication.
Shinbrot E, Henninger EE, Weinhold N, Covington KR, Göksenin AY, Schultz N, Chao H, Doddapaneni H, Muzny DM, Gibbs RA, Sander C, Pursell ZF, Wheeler DA.
Shinbrot E, et al. Among authors: henninger ee.
Genome Res. 2014 Nov;24(11):1740-50. doi: 10.1101/gr.174789.114. Epub 2014 Sep 16.
Genome Res. 2014.
PMID: 25228659
Free PMC article.
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Evidence for the kinetic partitioning of polymerase activity on G-quadruplex DNA.
Eddy S, Maddukuri L, Ketkar A, Zafar MK, Henninger EE, Pursell ZF, Eoff RL.
Eddy S, et al. Among authors: henninger ee.
Biochemistry. 2015 May 26;54(20):3218-30. doi: 10.1021/acs.biochem.5b00060. Epub 2015 May 11.
Biochemistry. 2015.
PMID: 25903680
Free PMC article.
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