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Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).
Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I. Rosenhouse-Dantsker A, et al. J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20. J Biol Chem. 2012. PMID: 22995912 Free PMC article.
Cholesterol increases the open probability of cardiac KACh currents.
Bukiya AN, Osborn CV, Kuntamallappanavar G, Toth PT, Baki L, Kowalsky G, Oh MJ, Dopico AM, Levitan I, Rosenhouse-Dantsker A. Bukiya AN, et al. Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13. doi: 10.1016/j.bbamem.2015.07.007. Epub 2015 Jul 18. Biochim Biophys Acta. 2015. PMID: 26196595 Free article.
221 results