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Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.
Hernández G, Ramírez MJ, Minguillón J, Quiles P, Ruiz de Garibay G, Aza-Carmona M, Bogliolo M, Pujol R, Prados-Carvajal R, Fernández J, García N, López A, Gutiérrez-Enríquez S, Diez O, Benítez J, Salinas M, Teulé A, Brunet J, Radice P, Peterlongo P, Schindler D, Huertas P, Puente XS, Lázaro C, Pujana MÀ, Surrallés J. Hernández G, et al. Among authors: huertas p. Nat Commun. 2018 Mar 6;9(1):967. doi: 10.1038/s41467-018-03433-3. Nat Commun. 2018. PMID: 29511213 Free PMC article.
BRCA1 accelerates CtIP-mediated DNA-end resection.
Cruz-García A, López-Saavedra A, Huertas P. Cruz-García A, et al. Among authors: huertas p. Cell Rep. 2014 Oct 23;9(2):451-9. doi: 10.1016/j.celrep.2014.08.076. Epub 2014 Oct 9. Cell Rep. 2014. PMID: 25310973 Free article.
DNA end resection requires constitutive sumoylation of CtIP by CBX4.
Soria-Bretones I, Cepeda-García C, Checa-Rodriguez C, Heyer V, Reina-San-Martin B, Soutoglou E, Huertas P. Soria-Bretones I, et al. Among authors: huertas p. Nat Commun. 2017 Jul 24;8(1):113. doi: 10.1038/s41467-017-00183-6. Nat Commun. 2017. PMID: 28740167 Free PMC article.
The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
Baranes-Bachar K, Levy-Barda A, Oehler J, Reid DA, Soria-Bretones I, Voss TC, Chung D, Park Y, Liu C, Yoon JB, Li W, Dellaire G, Misteli T, Huertas P, Rothenberg E, Ramadan K, Ziv Y, Shiloh Y. Baranes-Bachar K, et al. Among authors: huertas p. Mol Cell. 2018 Mar 1;69(5):866-878.e7. doi: 10.1016/j.molcel.2018.02.002. Mol Cell. 2018. PMID: 29499138 Free PMC article.
Controlling the balance between chromosome break repair pathways.
Jimeno S, Mejías-Navarro F, Prados-Carvajal R, Huertas P. Jimeno S, et al. Among authors: huertas p. Adv Protein Chem Struct Biol. 2019;115:95-134. doi: 10.1016/bs.apcsb.2018.10.004. Epub 2018 Dec 5. Adv Protein Chem Struct Biol. 2019. PMID: 30798939 Review.
86 results