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Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
Yan Y, An J, Yang Y, Wu D, Bai Y, Cao W, Ma L, Chen J, Yu Z, He Y, Jin X, Pan Y, Ma T, Wang S, Hou X, Weroha SJ, Karnes RJ, Zhang J, Westendorf JJ, Wang L, Chen Y, Xu W, Zhu R, Wang D, Huang H. Yan Y, et al. Among authors: chen j, chen y. EMBO Mol Med. 2018 Apr;10(4):e8478. doi: 10.15252/emmm.201708478. EMBO Mol Med. 2018. PMID: 29523594 Free PMC article.
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.
Zhang P, Wang D, Zhao Y, Ren S, Gao K, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H. Zhang P, et al. Among authors: chen y. Nat Med. 2017 Sep;23(9):1055-1062. doi: 10.1038/nm.4379. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805822 Free PMC article.
The potential of organoids in urological cancer research.
Wang S, Gao D, Chen Y. Wang S, et al. Among authors: chen y. Nat Rev Urol. 2017 Jul;14(7):401-414. doi: 10.1038/nrurol.2017.65. Epub 2017 May 23. Nat Rev Urol. 2017. PMID: 28534535 Free PMC article. Review.
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Dai X, et al. Among authors: chen t, chen y. Nat Med. 2017 Sep;23(9):1063-1071. doi: 10.1038/nm.4378. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805820 Free PMC article.
SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.
Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA, Barbieri CE. Blattner M, et al. Among authors: chen y. Cancer Cell. 2017 Mar 13;31(3):436-451. doi: 10.1016/j.ccell.2017.02.004. Cancer Cell. 2017. PMID: 28292441 Free PMC article.
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Mao N, Gao D, Hu W, Gadal S, Hieronymus H, Wang S, Lee YS, Sullivan P, Zhang Z, Choi D, Rosen N, Sawyers CL, Gopalan A, Chen Y, Carver BS. Mao N, et al. Among authors: chen y. Cancer Res. 2020 Apr 1;80(7):1428-1437. doi: 10.1158/0008-5472.CAN-19-1394. Epub 2020 Feb 3. Cancer Res. 2020. PMID: 32015092 Free PMC article.
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