Narayan P - Search Results

1

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity.

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner JM, Fanning S, Narayan P, Barrasa MI, Pincus D, Landgraf D, Nelson J, Hesse WR, Costanzo M; AMP T2D-GENES Consortium; Myers CL, Boone C, Florez JC, Lindquist S. Kayatekin C, et al. Among authors: narayan p. Cell. 2018 Mar 22;173(1):62-73.e9. doi: 10.1016/j.cell.2018.02.026. Epub 2018 Mar 8. Cell. 2018. PMID: 29526462 Free PMC article.

2

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4.

Narayan P, Sienski G, Bonner JM, Lin YT, Seo J, Baru V, Haque A, Milo B, Akay LA, Graziosi A, Freyzon Y, Landgraf D, Hesse WR, Valastyan J, Barrasa MI, Tsai LH, Lindquist S. Narayan P, et al. Cell Rep. 2020 Oct 6;33(1):108224. doi: 10.1016/j.celrep.2020.108224. Cell Rep. 2020. PMID: 33027662 Free PMC article.

3

Combating neurodegenerative disease with chemical probes and model systems.

Narayan P, Ehsani S, Lindquist S. Narayan P, et al. Nat Chem Biol. 2014 Nov;10(11):911-20. doi: 10.1038/nchembio.1663. Epub 2014 Oct 17. Nat Chem Biol. 2014. PMID: 25325702 Review.

4

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.

Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S. Matlack KE, et al. Among authors: narayan p. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4013-8. doi: 10.1073/pnas.1402228111. Epub 2014 Mar 3. Proc Natl Acad Sci U S A. 2014. PMID: 24591589 Free PMC article.

5

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia.

Sienski G, Narayan P, Bonner JM, Kory N, Boland S, Arczewska AA, Ralvenius WT, Akay L, Lockshin E, He L, Milo B, Graziosi A, Baru V, Lewis CA, Kellis M, Sabatini DM, Tsai LH, Lindquist S. Sienski G, et al. Among authors: narayan p. Sci Transl Med. 2021 Mar 3;13(583):eaaz4564. doi: 10.1126/scitranslmed.aaz4564. Sci Transl Med. 2021. PMID: 33658354 Free PMC article.

6

Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones.

Narayan P, Meehan S, Carver JA, Wilson MR, Dobson CM, Klenerman D. Narayan P, et al. Biochemistry. 2012 Nov 20;51(46):9270-6. doi: 10.1021/bi301277k. Epub 2012 Nov 8. Biochemistry. 2012. PMID: 23106396 Free PMC article.

7

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide.

Narayan P, Orte A, Clarke RW, Bolognesi B, Hook S, Ganzinger KA, Meehan S, Wilson MR, Dobson CM, Klenerman D. Narayan P, et al. Nat Struct Mol Biol. 2011 Dec 18;19(1):79-83. doi: 10.1038/nsmb.2191. Nat Struct Mol Biol. 2011. PMID: 22179788 Free PMC article.

8

Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage.

Narayan P, Holmström KM, Kim DH, Whitcomb DJ, Wilson MR, St George-Hyslop P, Wood NW, Dobson CM, Cho K, Abramov AY, Klenerman D. Narayan P, et al. Biochemistry. 2014 Apr 22;53(15):2442-53. doi: 10.1021/bi401606f. Epub 2014 Apr 9. Biochemistry. 2014. PMID: 24717093 Free PMC article.

9

Single-molecule imaging reveals that small amyloid-β1-42 oligomers interact with the cellular prion protein (PrP(C)).

Ganzinger KA, Narayan P, Qamar SS, Weimann L, Ranasinghe RT, Aguzzi A, Dobson CM, McColl J, St George-Hyslop P, Klenerman D. Ganzinger KA, et al. Among authors: narayan p. Chembiochem. 2014 Nov 24;15(17):2515-21. doi: 10.1002/cbic.201402377. Epub 2014 Oct 7. Chembiochem. 2014. PMID: 25294384 Free PMC article.

10

Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms.

Iljina M, Garcia GA, Dear AJ, Flint J, Narayan P, Michaels TC, Dobson CM, Frenkel D, Knowles TP, Klenerman D. Iljina M, et al. Among authors: narayan p. Sci Rep. 2016 Jun 27;6:28658. doi: 10.1038/srep28658. Sci Rep. 2016. PMID: 27346247 Free PMC article.

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