Taunton J - Search Results

1

Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.

Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. Ogbechi J, et al. Among authors: taunton j. Cell Death Dis. 2018 Mar 14;9(3):397. doi: 10.1038/s41419-018-0427-y. Cell Death Dis. 2018. PMID: 29540678 Free PMC article.

2

Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.

Maifeld SV, MacKinnon AL, Garrison JL, Sharma A, Kunkel EJ, Hegde RS, Taunton J. Maifeld SV, et al. Among authors: taunton j. Chem Biol. 2011 Sep 23;18(9):1082-8. doi: 10.1016/j.chembiol.2011.06.015. Chem Biol. 2011. PMID: 21944747 Free PMC article.

3

Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.

Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO. Paatero AO, et al. Among authors: taunton j. Cell Chem Biol. 2016 May 19;23(5):561-566. doi: 10.1016/j.chembiol.2016.04.008. Cell Chem Biol. 2016. PMID: 27203376 Free article.

4

Mycolactone subverts immunity by selectively blocking the Sec61 translocon.

Baron L, Paatero AO, Morel JD, Impens F, Guenin-Macé L, Saint-Auret S, Blanchard N, Dillmann R, Niang F, Pellegrini S, Taunton J, Paavilainen VO, Demangel C. Baron L, et al. Among authors: taunton j. J Exp Med. 2016 Dec 12;213(13):2885-2896. doi: 10.1084/jem.20160662. Epub 2016 Nov 7. J Exp Med. 2016. PMID: 27821549 Free PMC article.

5

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.

Garrison JL, Kunkel EJ, Hegde RS, Taunton J. Garrison JL, et al. Among authors: taunton j. Nature. 2005 Jul 14;436(7048):285-9. doi: 10.1038/nature03821. Nature. 2005. PMID: 16015336

6

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation.

MacKinnon AL, Garrison JL, Hegde RS, Taunton J. MacKinnon AL, et al. Among authors: taunton j. J Am Chem Soc. 2007 Nov 28;129(47):14560-1. doi: 10.1021/ja076250y. Epub 2007 Nov 6. J Am Chem Soc. 2007. PMID: 17983236 Free PMC article.

7

Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation.

Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K. Lakkaraju AK, et al. Among authors: taunton j. Mol Biol Cell. 2012 Jul;23(14):2712-22. doi: 10.1091/mbc.E12-03-0228. Epub 2012 May 30. Mol Biol Cell. 2012. PMID: 22648169 Free PMC article.

8

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

Mackinnon AL, Paavilainen VO, Sharma A, Hegde RS, Taunton J. Mackinnon AL, et al. Among authors: taunton j. Elife. 2014;3:e01483. doi: 10.7554/eLife.01483. Epub 2014 Feb 4. Elife. 2014. PMID: 24497544 Free PMC article.

9

Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum.

Ruiz-Saenz A, Sandhu M, Carrasco Y, Maglathlin RL, Taunton J, Moasser MM. Ruiz-Saenz A, et al. Among authors: taunton j. Oncogene. 2015 Oct 8;34(41):5288-94. doi: 10.1038/onc.2014.455. Epub 2015 Jan 26. Oncogene. 2015. PMID: 25619841 Free PMC article.

10

MAGI1 as a link between endothelial activation and ER stress drives atherosclerosis.

Abe JI, Ko KA, Kotla S, Wang Y, Paez-Mayorga J, Shin IJ, Imanishi M, Vu HT, Tao Y, Leiva-Juarez MM, Thomas TN, Medina JL, Won JH, Fujii Y, Giancursio CJ, McBeath E, Shin JH, Guzman L, Abe RJ, Taunton J, Mochizuki N, Faubion W, Cooke JP, Fujiwara K, Evans SE, Le NT. Abe JI, et al. Among authors: taunton j. JCI Insight. 2019 Apr 4;4(7):e125570. doi: 10.1172/jci.insight.125570. eCollection 2019 Apr 4. JCI Insight. 2019. PMID: 30944250 Free PMC article.

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