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Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response.
Temko D, Van Gool IC, Rayner E, Glaire M, Makino S, Brown M, Chegwidden L, Palles C, Depreeuw J, Beggs A, Stathopoulou C, Mason J, Baker AM, Williams M, Cerundolo V, Rei M, Taylor JC, Schuh A, Ahmed A, Amant F, Lambrechts D, Smit VT, Bosse T, Graham TA, Church DN, Tomlinson I. Temko D, et al. Among authors: baker am. J Pathol. 2018 Jul;245(3):283-296. doi: 10.1002/path.5081. Epub 2018 Apr 30. J Pathol. 2018. PMID: 29604063 Free PMC article.
Tumour Cell Heterogeneity.
Gay L, Baker AM, Graham TA. Gay L, et al. Among authors: baker am. F1000Res. 2016 Feb 29;5:F1000 Faculty Rev-238. doi: 10.12688/f1000research.7210.1. eCollection 2016. F1000Res. 2016. PMID: 26973786 Free PMC article. Review.
Revealing human intestinal stem cell and crypt dynamics.
Baker AM, Graham TA. Baker AM, et al. Mol Cell Oncol. 2014 Dec 23;1(3):e970069. doi: 10.4161/23723548.2014.970069. eCollection 2014 Jul-Sep. Mol Cell Oncol. 2014. PMID: 27308359 Free PMC article.
Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus.
Martinez P, Timmer MR, Lau CT, Calpe S, Sancho-Serra Mdel C, Straub D, Baker AM, Meijer SL, Kate FJ, Mallant-Hent RC, Naber AH, van Oijen AH, Baak LC, Scholten P, Böhmer CJ, Fockens P, Bergman JJ, Maley CC, Graham TA, Krishnadath KK. Martinez P, et al. Among authors: baker am. Nat Commun. 2016 Aug 19;7:12158. doi: 10.1038/ncomms12158. Nat Commun. 2016. PMID: 27538785 Free PMC article.
Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution.
Baker AM, Huang W, Wang XM, Jansen M, Ma XJ, Kim J, Anderson CM, Wu X, Pan L, Su N, Luo Y, Domingo E, Heide T, Sottoriva A, Lewis A, Beggs AD, Wright NA, Rodriguez-Justo M, Park E, Tomlinson I, Graham TA. Baker AM, et al. Nat Commun. 2017 Dec 8;8(1):1998. doi: 10.1038/s41467-017-02295-5. Nat Commun. 2017. PMID: 29222441 Free PMC article.
Evolutionary history of human colitis-associated colorectal cancer.
Baker AM, Cross W, Curtius K, Al Bakir I, Choi CR, Davis HL, Temko D, Biswas S, Martinez P, Williams MJ, Lindsay JO, Feakins R, Vega R, Hayes SJ, Tomlinson IPM, McDonald SAC, Moorghen M, Silver A, East JE, Wright NA, Wang LM, Rodriguez-Justo M, Jansen M, Hart AL, Leedham SJ, Graham TA. Baker AM, et al. Gut. 2019 Jun;68(6):985-995. doi: 10.1136/gutjnl-2018-316191. Epub 2018 Jul 10. Gut. 2019. PMID: 29991641 Free PMC article.
231 results