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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G. Huber KV, et al. Among authors: loizou ji. Nature. 2014 Apr 10;508(7495):222-7. doi: 10.1038/nature13194. Epub 2014 Apr 2. Nature. 2014. PMID: 24695225 Free PMC article.
DNA Repair Cofactors ATMIN and NBS1 Are Required to Suppress T Cell Activation.
Prochazkova J, Sakaguchi S, Owusu M, Mazouzi A, Wiedner M, Velimezi G, Moder M, Turchinovich G, Hladik A, Gurnhofer E, Hayday A, Behrens A, Knapp S, Kenner L, Ellmeier W, Loizou JI. Prochazkova J, et al. Among authors: loizou ji. PLoS Genet. 2015 Nov 6;11(11):e1005645. doi: 10.1371/journal.pgen.1005645. eCollection 2015 Nov. PLoS Genet. 2015. PMID: 26544571 Free PMC article.
MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Smida M, Fece de la Cruz F, Kerzendorfer C, Uras IZ, Mair B, Mazouzi A, Suchankova T, Konopka T, Katz AM, Paz K, Nagy-Bojarszky K, Muellner MK, Bago-Horvath Z, Haura EB, Loizou JI, Nijman SM. Smida M, et al. Among authors: loizou ji. Nat Commun. 2016 Dec 6;7:13701. doi: 10.1038/ncomms13701. Nat Commun. 2016. PMID: 27922010 Free PMC article.
Parallel genome-wide screens identify synthetic viable interactions between the BLM helicase complex and Fanconi anemia.
Moder M, Velimezi G, Owusu M, Mazouzi A, Wiedner M, Ferreira da Silva J, Robinson-Garcia L, Schischlik F, Slavkovsky R, Kralovics R, Schuster M, Bock C, Ideker T, Jackson SP, Menche J, Loizou JI. Moder M, et al. Among authors: loizou ji. Nat Commun. 2017 Nov 1;8(1):1238. doi: 10.1038/s41467-017-01439-x. Nat Commun. 2017. PMID: 29089570 Free PMC article.
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.
Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI. Velimezi G, et al. Among authors: loizou ji. Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z. Nat Commun. 2018. PMID: 29891926 Free PMC article.
Mapping the Human Kinome in Response to DNA Damage.
Owusu M, Bannauer P, Ferreira da Silva J, Mourikis TP, Jones A, Májek P, Caldera M, Wiedner M, Lardeau CH, Mueller AC, Menche J, Kubicek S, Ciccarelli FD, Loizou JI. Owusu M, et al. Among authors: loizou ji. Cell Rep. 2019 Jan 15;26(3):555-563.e6. doi: 10.1016/j.celrep.2018.12.087. Cell Rep. 2019. PMID: 30650350 Free article.
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