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Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics.
Tourdot BE, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein LC, Bray PF, Tall GG, Holinstat M. Tourdot BE, et al. Among authors: edelstein lc. Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1632-1643. doi: 10.1161/ATVBAHA.118.311112. Epub 2018 May 10. Arterioscler Thromb Vasc Biol. 2018. PMID: 29748334 Free PMC article.
The protease-activated receptor 4 Ala120Thr variant alters platelet responsiveness to low-dose thrombin and protease-activated receptor 4 desensitization, and is blocked by non-competitive P2Y12 inhibition.
Whitley MJ, Henke DM, Ghazi A, Nieman M, Stoller M, Simon LM, Chen E, Vesci J, Holinstat M, McKenzie SE, Shaw CA, Edelstein LC, Bray PF. Whitley MJ, et al. Among authors: edelstein lc. J Thromb Haemost. 2018 Dec;16(12):2501-2514. doi: 10.1111/jth.14318. Epub 2018 Nov 22. J Thromb Haemost. 2018. PMID: 30347494 Free PMC article.
TULA-2 (T-Cell Ubiquitin Ligand-2) Inhibits the Platelet Fc Receptor for IgG IIA (FcγRIIA) Signaling Pathway and Heparin-Induced Thrombocytopenia in Mice.
Zhou Y, Abraham S, Renna S, Edelstein LC, Dangelmaier CA, Tsygankov AY, Kunapuli SP, Bray PF, McKenzie SE. Zhou Y, et al. Among authors: edelstein lc. Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2315-2323. doi: 10.1161/ATVBAHA.116.307979. Epub 2016 Oct 20. Arterioscler Thromb Vasc Biol. 2016. PMID: 27765766
MicroRNAs in platelet production and activation.
Edelstein LC, McKenzie SE, Shaw C, Holinstat MA, Kunapuli SP, Bray PF. Edelstein LC, et al. J Thromb Haemost. 2013 Jun;11 Suppl 1:340-50. doi: 10.1111/jth.12214. J Thromb Haemost. 2013. PMID: 23809137 Free article. Review.
MicroRNAs in platelet production and activation.
Edelstein LC, Bray PF. Edelstein LC, et al. Blood. 2011 May 19;117(20):5289-96. doi: 10.1182/blood-2011-01-292011. Epub 2011 Mar 1. Blood. 2011. PMID: 21364189 Free PMC article. Review.
Human genome-wide association and mouse knockout approaches identify platelet supervillin as an inhibitor of thrombus formation under shear stress.
Edelstein LC, Luna EJ, Gibson IB, Bray M, Jin Y, Kondkar A, Nagalla S, Hadjout-Rabi N, Smith TC, Covarrubias D, Jones SN, Ahmad F, Stolla M, Kong X, Fang Z, Bergmeier W, Shaw C, Leal SM, Bray PF. Edelstein LC, et al. Circulation. 2012 Jun 5;125(22):2762-71. doi: 10.1161/CIRCULATIONAHA.112.091462. Epub 2012 May 1. Circulation. 2012. PMID: 22550155 Free PMC article.
Small RNAs as potential platelet therapeutics.
Edelstein LC, Bray PF. Edelstein LC, et al. Handb Exp Pharmacol. 2012;(210):435-45. doi: 10.1007/978-3-642-29423-5_17. Handb Exp Pharmacol. 2012. PMID: 22918741 Review.
42 results