Shen B - Search Results

1

Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme.

Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Wang N, et al. Among authors: shen b. Nat Chem Biol. 2018 Jul;14(7):730-737. doi: 10.1038/s41589-018-0061-0. Epub 2018 Jun 4. Nat Chem Biol. 2018. PMID: 29867143 Free PMC article.

2

Structure of the bifunctional acyltransferase/decarboxylase LnmK from the leinamycin biosynthetic pathway revealing novel activity for a double-hot-dog fold.

Lohman JR, Bingman CA, Phillips GN Jr, Shen B. Lohman JR, et al. Among authors: shen b. Biochemistry. 2013 Feb 5;52(5):902-11. doi: 10.1021/bi301652y. Epub 2013 Jan 24. Biochemistry. 2013. PMID: 23320975 Free PMC article.

In vitro biochemical investigation confirmed that LnmK is a bifunctional acyltransferase/decarboxylase (AT/DC) that catalyzes first self-acylation using methylmalonyl-CoA as a substrate and subsequently transacylation of the methylmalonyl group to the phosphopantetheinyl group of …

In vitro biochemical investigation confirmed that LnmK is a bifunctional acyltransferase/decarboxylase (AT/DC) that catalyzes first self-acy …

3

Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.

Xie P, Ma M, Rateb ME, Shaaban KA, Yu Z, Huang SX, Zhao LX, Zhu X, Yan Y, Peterson RM, Lohman JR, Yang D, Yin M, Rudolf JD, Jiang Y, Duan Y, Shen B. Xie P, et al. Among authors: shen b. J Nat Prod. 2014 Feb 28;77(2):377-87. doi: 10.1021/np401063s. Epub 2014 Jan 31. J Nat Prod. 2014. PMID: 24484381 Free PMC article.

4

Mechanisms of self-resistance in the platensimycin- and platencin-producing Streptomyces platensis MA7327 and MA7339 strains.

Peterson RM, Huang T, Rudolf JD, Smanski MJ, Shen B. Peterson RM, et al. Among authors: shen b. Chem Biol. 2014 Mar 20;21(3):389-397. doi: 10.1016/j.chembiol.2014.01.005. Epub 2014 Feb 20. Chem Biol. 2014. PMID: 24560608 Free PMC article.

5

Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.

Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B. Ge HM, et al. Among authors: shen b. Org Lett. 2014 Aug 1;16(15):3958-61. doi: 10.1021/ol501767v. Epub 2014 Jul 14. Org Lett. 2014. PMID: 25019332 Free PMC article.

6

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.

Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B. Lohman JR, et al. Among authors: shen b. Proteins. 2014 Jul;82(7):1210-8. doi: 10.1002/prot.24485. Proteins. 2014. PMID: 25050442 Free PMC article.

7

Strain prioritization for natural product discovery by a high-throughput real-time PCR method.

Hindra, Huang T, Yang D, Rudolf JD, Xie P, Xie G, Teng Q, Lohman JR, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B. Hindra, et al. Among authors: shen b. J Nat Prod. 2014 Oct 24;77(10):2296-303. doi: 10.1021/np5006168. Epub 2014 Sep 19. J Nat Prod. 2014. PMID: 25238028 Free PMC article.

8

Enediynes: Exploration of microbial genomics to discover new anticancer drug leads.

Shen B, Hindra, Yan X, Huang T, Ge H, Yang D, Teng Q, Rudolf JD, Lohman JR. Shen B, et al. Bioorg Med Chem Lett. 2015 Jan 1;25(1):9-15. doi: 10.1016/j.bmcl.2014.11.019. Epub 2014 Nov 14. Bioorg Med Chem Lett. 2015. PMID: 25434000 Free PMC article. Review.

9

A genetically amenable platensimycin- and platencin-overproducer as a platform for biosynthetic explorations: a showcase of PtmO4, a long-chain acyl-CoA dehydrogenase.

Rudolf JD, Dong LB, Huang T, Shen B. Rudolf JD, et al. Among authors: shen b. Mol Biosyst. 2015 Oct;11(10):2717-26. doi: 10.1039/c5mb00303b. Mol Biosyst. 2015. PMID: 26055255 Free PMC article.

10

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

Rudolf JD, Yan X, Shen B. Rudolf JD, et al. Among authors: shen b. J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):261-76. doi: 10.1007/s10295-015-1671-0. Epub 2015 Aug 29. J Ind Microbiol Biotechnol. 2016. PMID: 26318027 Free PMC article.

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