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Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.
Simovski B, Kanduri C, Gundersen S, Titov D, Domanska D, Bock C, Bossini-Castillo L, Chikina M, Favorov A, Layer RM, Mironov AA, Quinlan AR, Sheffield NC, Trynka G, Sandve GK. Simovski B, et al. Among authors: trynka g. Nucleic Acids Res. 2018 Jul 2;46(W1):W186-W193. doi: 10.1093/nar/gky474. Nucleic Acids Res. 2018. PMID: 29873782 Free PMC article.
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.
Soskic B, Cano-Gamez E, Smyth DJ, Rowan WC, Nakic N, Esparza-Gordillo J, Bossini-Castillo L, Tough DF, Larminie CGC, Bronson PG, Willé D, Trynka G. Soskic B, et al. Among authors: trynka g. Nat Genet. 2019 Oct;51(10):1486-1493. doi: 10.1038/s41588-019-0493-9. Epub 2019 Sep 23. Nat Genet. 2019. PMID: 31548716 Free PMC article.
Gene expression variability across cells and species shapes innate immunity.
Hagai T, Chen X, Miragaia RJ, Rostom R, Gomes T, Kunowska N, Henriksson J, Park JE, Proserpio V, Donati G, Bossini-Castillo L, Vieira Braga FA, Naamati G, Fletcher J, Stephenson E, Vegh P, Trynka G, Kondova I, Dennis M, Haniffa M, Nourmohammad A, Lässig M, Teichmann SA. Hagai T, et al. Among authors: trynka g. Nature. 2018 Nov;563(7730):197-202. doi: 10.1038/s41586-018-0657-2. Epub 2018 Oct 24. Nature. 2018. PMID: 30356220 Free PMC article.
Immune disease variants modulate gene expression in regulatory CD4+ T cells.
Bossini-Castillo L, Glinos DA, Kunowska N, Golda G, Lamikanra AA, Spitzer M, Soskic B, Cano-Gamez E, Smyth DJ, Cattermole C, Alasoo K, Mann A, Kundu K, Lorenc A, Soranzo N, Dunham I, Roberts DJ, Trynka G. Bossini-Castillo L, et al. Among authors: trynka g. Cell Genom. 2022 Apr 13;2(4):None. doi: 10.1016/j.xgen.2022.100117. Cell Genom. 2022. PMID: 35591976 Free PMC article.
Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation.
Soskic B, Cano-Gamez E, Smyth DJ, Ambridge K, Ke Z, Matte JC, Bossini-Castillo L, Kaplanis J, Ramirez-Navarro L, Lorenc A, Nakic N, Esparza-Gordillo J, Rowan W, Wille D, Tough DF, Bronson PG, Trynka G. Soskic B, et al. Among authors: trynka g. Nat Genet. 2022 Jun;54(6):817-826. doi: 10.1038/s41588-022-01066-3. Epub 2022 May 26. Nat Genet. 2022. PMID: 35618845 Free PMC article.
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Wain LV, Shrine N, Artigas MS, Erzurumluoglu AM, Noyvert B, Bossini-Castillo L, Obeidat M, Henry AP, Portelli MA, Hall RJ, Billington CK, Rimington TL, Fenech AG, John C, Blake T, Jackson VE, Allen RJ, Prins BP; Understanding Society Scientific Group; Campbell A, Porteous DJ, Jarvelin MR, Wielscher M, James AL, Hui J, Wareham NJ, Zhao JH, Wilson JF, Joshi PK, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch NM, Karrasch S, Gieger C, Deary IJ, Harris SE, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr SM, Polasek O, Kähönen M, Surakka I, Vitart V, Hayward C, Lehtimäki T, Raitakari OT, Evans DM, Henderson AJ, Pennell CE, Wang CA, Sly PD, Wan ES, Busch R, Hobbs BD, Litonjua AA, Sparrow DW, Gulsvik A, Bakke PS, Crapo JD, Beaty TH, Hansel NN, Mathias RA, Ruczinski I, Barnes KC, Bossé Y, Joubert P, van den Berge M, Brandsma CA, Paré PD, Sin DD, Nickle DC, Hao K, Gottesman O, Dewey FE, Bruse SE, Carey DJ, Kirchner HL; Geisinger-Regeneron DiscovEHR Collaboration; Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger EP, Loos RJ, Walters RG, Chen Z, Millwood IY, Vaucher J, Kurmi OP, Li L, Hansell AL, Brightling C, Zeggini E, Cho MH, Silv… See abstract for full author list ➔ Wain LV, et al. Among authors: trynka g. Nat Genet. 2017 Mar;49(3):416-425. doi: 10.1038/ng.3787. Epub 2017 Feb 6. Nat Genet. 2017. PMID: 28166213 Free PMC article.
A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells.
Nasrallah R, Imianowski CJ, Bossini-Castillo L, Grant FM, Dogan M, Placek L, Kozhaya L, Kuo P, Sadiyah F, Whiteside SK, Mumbach MR, Glinos D, Vardaka P, Whyte CE, Lozano T, Fujita T, Fujii H, Liston A, Andrews S, Cozzani A, Yang J, Mitra S, Lugli E, Chang HY, Unutmaz D, Trynka G, Roychoudhuri R. Nasrallah R, et al. Among authors: trynka g. Nature. 2020 Jul;583(7816):447-452. doi: 10.1038/s41586-020-2296-7. Epub 2020 May 13. Nature. 2020. PMID: 32499651 Free PMC article.
Enhancers looping to target genes.
Trynka G. Trynka G. Nat Genet. 2017 Oct 27;49(11):1564-1565. doi: 10.1038/ng.3982. Nat Genet. 2017. PMID: 29074944
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines.
Cano-Gamez E, Soskic B, Roumeliotis TI, So E, Smyth DJ, Baldrighi M, Willé D, Nakic N, Esparza-Gordillo J, Larminie CGC, Bronson PG, Tough DF, Rowan WC, Choudhary JS, Trynka G. Cano-Gamez E, et al. Among authors: trynka g. Nat Commun. 2020 Apr 14;11(1):1801. doi: 10.1038/s41467-020-15543-y. Nat Commun. 2020. PMID: 32286271 Free PMC article.
77 results