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hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.
Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L. Segeritz CP, et al. Among authors: lomas da. J Hepatol. 2018 Oct;69(4):851-860. doi: 10.1016/j.jhep.2018.05.028. Epub 2018 Jun 5. J Hepatol. 2018. PMID: 29879455 Free PMC article.
Nucleation of alpha 1-antichymotrypsin polymerization.
Crowther DC, Serpell LC, Dafforn TR, Gooptu B, Lomas DA. Crowther DC, et al. Among authors: lomas da. Biochemistry. 2003 Mar 4;42(8):2355-63. doi: 10.1021/bi0259305. Biochemistry. 2003. PMID: 12600202
Alpha(1)-antitrypsin deficiency, liver disease and emphysema.
Parfrey H, Mahadeva R, Lomas DA. Parfrey H, et al. Among authors: lomas da. Int J Biochem Cell Biol. 2003 Jul;35(7):1009-14. doi: 10.1016/s1357-2725(02)00250-9. Int J Biochem Cell Biol. 2003. PMID: 12672469 Review.
Intracellular serpins, firewalls and tissue necrosis.
Marciniak SJ, Lomas DA. Marciniak SJ, et al. Among authors: lomas da. Trends Cell Biol. 2008 Feb;18(2):45-7. doi: 10.1016/j.tcb.2007.11.006. Epub 2008 Jan 22. Trends Cell Biol. 2008. PMID: 18215520
349 results