Crowther DC - Search Results

1

Prion protein stabilizes amyloid-β (Aβ) oligomers and enhances Aβ neurotoxicity in a Drosophila model of Alzheimer's disease.

Younan ND, Chen KF, Rose RS, Crowther DC, Viles JH. Younan ND, et al. Among authors: crowther dc. J Biol Chem. 2018 Aug 24;293(34):13090-13099. doi: 10.1074/jbc.RA118.003319. Epub 2018 Jun 10. J Biol Chem. 2018. PMID: 29887525 Free PMC article.

2

Insights into amyloid disease from fly models.

Chen KF, Crowther DC. Chen KF, et al. Among authors: crowther dc. Essays Biochem. 2014;56:69-83. doi: 10.1042/bse0560069. Essays Biochem. 2014. PMID: 25131587

3

Functional genomics in Drosophila models of human disease.

Chen KF, Crowther DC. Chen KF, et al. Among authors: crowther dc. Brief Funct Genomics. 2012 Sep;11(5):405-15. doi: 10.1093/bfgp/els038. Epub 2012 Aug 22. Brief Funct Genomics. 2012. PMID: 22914042 Review.

4

The central molecular clock is robust in the face of behavioural arrhythmia in a Drosophila model of Alzheimer's disease.

Chen KF, Possidente B, Lomas DA, Crowther DC. Chen KF, et al. Among authors: crowther dc. Dis Model Mech. 2014 Apr;7(4):445-58. doi: 10.1242/dmm.014134. Epub 2014 Feb 26. Dis Model Mech. 2014. PMID: 24574361 Free PMC article.

5

Central and peripheral circadian clocks and their role in Alzheimer's disease.

Chauhan R, Chen KF, Kent BA, Crowther DC. Chauhan R, et al. Among authors: crowther dc. Dis Model Mech. 2017 Oct 1;10(10):1187-1199. doi: 10.1242/dmm.030627. Dis Model Mech. 2017. PMID: 28993311 Free PMC article. Review.

6

Expression in drosophila of tandem amyloid β peptides provides insights into links between aggregation and neurotoxicity.

Speretta E, Jahn TR, Tartaglia GG, Favrin G, Barros TP, Imarisio S, Lomas DA, Luheshi LM, Crowther DC, Dobson CM. Speretta E, et al. Among authors: crowther dc. J Biol Chem. 2012 Jun 8;287(24):20748-54. doi: 10.1074/jbc.M112.350124. Epub 2012 Mar 29. J Biol Chem. 2012. PMID: 22461632 Free PMC article.

7

Flyglow: Single-fly observations of simultaneous molecular and behavioural circadian oscillations in controls and an Alzheimer's model.

Khabirova E, Chen KF, O'Neill JS, Crowther DC. Khabirova E, et al. Among authors: crowther dc. Sci Rep. 2016 Sep 23;6:33759. doi: 10.1038/srep33759. Sci Rep. 2016. PMID: 27658441 Free PMC article.

8

Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

Kinghorn KJ, Crowther DC, Sharp LK, Nerelius C, Davis RL, Chang HT, Green C, Gubb DC, Johansson J, Lomas DA. Kinghorn KJ, et al. Among authors: crowther dc. J Biol Chem. 2006 Sep 29;281(39):29268-77. doi: 10.1074/jbc.M600690200. Epub 2006 Jul 17. J Biol Chem. 2006. PMID: 16849336 Free article.

9

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.

Costa R, Speretta E, Crowther DC, Cardoso I. Costa R, et al. Among authors: crowther dc. J Biol Chem. 2011 Dec 2;286(48):41647-41655. doi: 10.1074/jbc.M111.274548. Epub 2011 Oct 13. J Biol Chem. 2011. PMID: 21998304 Free PMC article.

10

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.

Liu B, Moloney A, Meehan S, Morris K, Thomas SE, Serpell LC, Hider R, Marciniak SJ, Lomas DA, Crowther DC. Liu B, et al. Among authors: crowther dc. J Biol Chem. 2011 Feb 11;286(6):4248-56. doi: 10.1074/jbc.M110.158980. Epub 2010 Dec 8. J Biol Chem. 2011. PMID: 21147772 Free PMC article.

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