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Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U. Oppelt A, et al. Among authors: kaschek d. NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018. NPJ Syst Biol Appl. 2018. PMID: 29900006 Free PMC article.
Model-based extension of high-throughput to high-content data.
Pfeifer AC, Kaschek D, Bachmann J, Klingmüller U, Timmer J. Pfeifer AC, et al. Among authors: kaschek d. BMC Syst Biol. 2010 Aug 5;4:106. doi: 10.1186/1752-0509-4-106. BMC Syst Biol. 2010. PMID: 20687942 Free PMC article.
Lessons learned from quantitative dynamical modeling in systems biology.
Raue A, Schilling M, Bachmann J, Matteson A, Schelker M, Kaschek D, Hug S, Kreutz C, Harms BD, Theis FJ, Klingmüller U, Timmer J. Raue A, et al. Among authors: kaschek d. PLoS One. 2013 Sep 30;8(9):e74335. doi: 10.1371/journal.pone.0074335. eCollection 2013. PLoS One. 2013. PMID: 24098642 Free PMC article.
Dynamic modeling of Nrf2 pathway activation in liver cells after toxicant exposure.
Hiemstra S, Fehling-Kaschek M, Kuijper IA, Bischoff LJM, Wijaya LS, Rosenblatt M, Esselink J, van Egmond A, Mos J, Beltman JB, Timmer J, van de Water B, Kaschek D. Hiemstra S, et al. Among authors: kaschek d. Sci Rep. 2022 May 5;12(1):7336. doi: 10.1038/s41598-022-10857-x. Sci Rep. 2022. PMID: 35513409 Free PMC article.
21 results